Placental transfer of Haemophilus influenzae type b antibodies in malnourished pregnant women
Placental transfer of Haemophilus influenzae type b antibodies in malnourished pregnant women
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DOI：
10.1590/s1413-86702008000100011
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发表时间：
2008-02-01
影响因子：
3.4
通讯作者：
Costa-Carvalho, Beatriz T.
中科院分区：
文献类型：
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作者：
Cavalcante, Rejane S.;Kopelman, Benjamin I.;Costa-Carvalho, Beatriz T.
本研究评价了营养不良孕妇（MN）、脐带血（CB）和2月龄和6月龄婴儿对B型流感嗜血杆菌（HiB）的接种反应，并与对照组（C）进行比较。28名营养不良的孕妇和29名孕妇对照在妊娠晚期用结合的Act-HIB（R）免疫。在免疫前、分娩期间（免疫后）和CB中采集所有血样。所有婴儿均按照正常疫苗接种计划接种Hib疫苗，并在2月龄和6月龄时收集血清。两组的多聚核糖基核糖醇磷酸（PRP）抗体水平相似。免疫前：MN 1.94 μ g/mL，C 1.68 μ g/mL;接种后：MN 18.53 μ g/mL和C 17.55 μ g/mL;来自MN的CB中为14.46 μ g/mL，来自C的CB中为17.04 μ g/mL。MN和C母亲的婴儿在2个月时分别为：5.18 μ g/mL和8.60 μ g/mL，6个月时：MN 3.42 μ g/mL和C 2.18 μ g/mL。两组研究的抗体水平相似（p = 0.485），但MN妊娠组的垂直传播率低14%。在MN妊娠组的所有新生儿中发现抗体水平>= 0.15 μ g/mL。MN妊娠组对Hib疫苗的免疫应答与C组相似，但PRP抗体垂直传播率比C组低14%，提示抗体在MN妊娠组内的传播效率较低。
This study evaluated the vaccination response to Haemophilus influenzae type b (Hib) in malnourished pregnant women (MN), cord blood (CB) and in infants at two and six months of age for comparison with a control group (C). Twenty-eight malnourished pregnant women and 29 pregnant controls were immunized with conjugated Act-HIB (R) in the third trimester of pregnancy. Blood samples were collected from all before the immunization, during labor (post immunization), and from CB. All infants were immunized with Hib vaccine according to normal vaccine schedule and sera were collected at two and six months of age. Antibody levels to polyribosylribitol phosphate (PRP) were similar for both groups. Preimmunization: MN 1.94 mu g/mL, C 1.68 mu g/mL; post-vaccination: MN 18.53 mu g/mL and C 17.55 mu g/mL; in CB from MN 14.46 mu g/mL and from C 17.04 mu g/mL. Infants from MN and C mothers presented respectively at two months: 5.18 mu g/mL and 8.60 mu g/mL and at six months: MN 3.42 mu g/mL and C 2.18 mu g/mL. Antibody levels were similar in both groups studied (p = 0.485), however the vertical transmission rate was 14% lower in the MN pregnant group. Levels of antibodies >= 0.15 mu g/mL were found in all newborns from the MN pregnant group. Pregnant MN presented an immunological response to Hib vaccine similar to group C, however, vertical transmission rate of antibodies to PRP in the MN pregnant group was 14% lower than that in C, suggesting a less efficient passage of antibodies within this group.