Effect of Inhaled Racemic and (R)-Albuterol on Airway Vascular Smooth Muscle Tone in Healthy and Asthmatic Subjects
Effect of Inhaled Racemic and (R)-Albuterol on Airway Vascular Smooth Muscle Tone in Healthy and Asthmatic Subjects
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吸入外消旋和 (R)-沙丁胺醇对健康和哮喘受试者气道血管平滑肌张力的影响
DOI：
10.1007/s00408-003-1022-1
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发表时间：
2003
期刊：
影响因子：
5
通讯作者：
Adam Wanner
中科院分区：
文献类型：
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作者：
Adriana Pereira;E. Mendes;T. Ferreira;Adam Wanner
虽然外消旋和（R）-沙丁胺醇对气流阻塞患者气道平滑肌张力的相对作用已被研究，但这两种药物在舒张气道血管平滑肌方面的比较效果尚不清楚。因此，我们确定了吸入外消旋和（R）-沙丁胺醇对气道粘膜血流的作用（
在11名健康受试者和10名轻度哮喘受试者中，将解剖死腔标准化作为气道血管平滑肌张力的指数。我们还监测了1秒用力呼气量（FEV 1）作为气道平滑肌张力的指标。基线平均值± SE
健康受试者为43.1 ± 1.5 µl.min−1.ml−1，哮喘受试者为53.4 ± 2.1 µl.min−1.ml−1（p < 0.01）。FEV 1的相应值分别为预测值的95.6 ± 1.4和86.8 ± 2.5%（p = 0.01）。外消旋和（R）-沙丁胺醇引起短暂的剂量依赖性增加，
在健康受试者中，但在哮喘受试者中没有;两种药物之间的反应没有差异。与健康受试者相比，哮喘患者的FEV 1往往增加更多，两种药物之间也没有差异。这些结果表明，外消旋和（R）-沙丁胺醇对气道血管平滑肌的作用相当，并表明哮喘患者对沙丁胺醇的气道血管平滑肌反应减弱与（S）-沙丁胺醇无关。
AbstractAlthough the relative effect of racemic and (R)-albuterol on airway smooth muscle tone have been investigated in patients with airflow obstruction, the comparative effectiveness of these drugs in relaxing airway vascular smooth muscle is unknown. Therefore, we determined the actions of inhaled racemic and (R)-albuterol on airway mucosal blood flow (
) normalized for anatomic dead space as an index of airway vascular smooth muscle tone in 11 healthy subjects and 10 subjects with mild asthma. We also monitored the forced expiratory volume in 1 second (FEV1) as an index of airway smooth muscle tone. Mean ± SE baseline
was 43.1 ± 1.5 µl.min−1.ml−1 in healthy subjects and 53.4 ± 2.1 µl.min−1.ml−1 in asthmatic subjects (p < 0.01). The corresponding values for FEV1 were 95.6 ± 1.4 and 86.8 ± 2.5% respectively, of predicted (p = 0.01). Racemic and (R)-albuterol caused a transient, dose-dependent increase of
in healthy, but not in asthmatic subjects; the responses were not different between the two drugs. The FEV1 tended to increase more in asthmatics than in healthy subjects, again without a difference between the two drugs. These results show that racemic and (R)-albuterol have comparable effects on airway vascular smooth muscle and suggest that the blunted airway vascular smooth muscle response to albuterol in asthmatics is not related to (S)-albuterol.