Pinpointing synaptic loss caused by Alzheimer's disease with fMRI
Pinpointing synaptic loss caused by Alzheimer's disease with fMRI
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DOI：
10.1155/2009/246892
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发表时间：
2009-01-01
影响因子：
2.8
通讯作者：
Fleisher, Adam
中科院分区：
文献类型：
--
作者：
Brickman, Adam M.;Small, Scott A.;Fleisher, Adam
阿尔茨海默病（AD）的早期阶段，在细胞丧失之前，独立于淀粉样斑块和神经原纤维缠结，会导致突触丧失，影响神经元的基础功能特性。原则上，突触损失可以通过测量ad诱导的基础功能变化来检测，或者通过测量基础变化之上的刺激诱发反应来检测。功能磁共振成像（fMRI）对基础变化和诱发反应都很敏感，因此有两种实验方法可以使用fMRI来精确定位阿尔茨海默氏症的突触丧失。在这篇综述中，我们将比较和对比这两种方法，以确定阿尔茨海默病突触丧失开始的时间和地点，并监测治疗效果。
During its earliest stage, before cell loss and independent of amyloid plaques and neurofibrillary tangles, Alzheimer's disease (AD) causes synaptic loss affecting the basal functional properties of neurons. In principle, synaptic loss can be detected by measuring AD-induced changes in basal function, or by measuring stimulus-evoked responses on top of basal changes. Functional magnetic resonance imaging (fMRI) is sensitive to both basal changes and evoked-responses, and there are therefore two experimental approaches in which fMRI can be used to pinpoint synaptic loss in AD. In this review, we will compare and contrast both approaches for pinpointing when and where synaptic loss in AD begins and for monitoring therapeutic efficacy.