Occurrence of foot-and-mouth disease virus serotypes in Uganda and Tanzania (2003 to 2015): a review and implications for prospective regional disease control.
Occurrence of foot-and-mouth disease virus serotypes in Uganda and Tanzania (2003 to 2015): a review and implications for prospective regional disease control.
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DOI：
10.5539/jas.v12n6p119
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发表时间：
2020-01-01
期刊：
影响因子：
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通讯作者：
Haydon, Daniel T.
中科院分区：
文献类型：
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作者：
Kerfua, Susan D.;Dhikusooka, Moses T.;Haydon, Daniel T.
地方性口蹄疫（FMD）给畜牧业带来了全球性的经济挑战。口蹄疫的渐进控制途径（PCP-FMD）规定了国家/地区减少口蹄疫病毒传播和影响的连续步骤。这些步骤依赖于对口蹄疫流行病学的理解和获得知识，以告知适当的疾病干预措施的发展，如疫苗接种和检疫计划。目前，乌干达和坦桑尼亚正处于五氯苯酚-口蹄疫的早期阶段。这项审查是为了确定2003年至2015年期间乌干达和坦桑尼亚的FMDV血清型分布。本文还介绍了这两个国家在同一时期使用的疫苗株，即流行的拓扑型。该综述突出了13年期间分别在乌干达和坦桑尼亚发生的4种（O、A、SAT 1和SAT 2）和5种（O、A、SAT 1、SAT 2和SAT 3）血清型。观察结果显示，这两个国家报告的O型和A型血清型分别属于东非2型（EA-2）和非洲型。坦桑尼亚的SAT 1病毒属于拓扑型I，与乌干达的SAT 1病毒属于拓扑型IV不同。同样，这两个国家的SAT 2属于不同的地形类型：坦桑尼亚的IV和乌干达的I。此外，这篇综述强调了乌干达和坦桑尼亚口蹄疫病毒血清型的空间分布，并强调了这两个国家具有高血清型多样性的地区。本文建议明确的疾病诊断，分子血清型特征和匹配的疫苗接种部署，以改善疾病控制。
Endemic foot-and-mouth disease (FMD) presents a global economic challenge to the livestock industry. The progressive control pathway for FMD (PCP-FMD) specifies successive steps through which a country/region can reduce FMD virus circulation and impact. These steps are reliant on understanding and obtaining knowledge on FMD epidemiology, to inform development of appropriate disease interventions like vaccination and quarantine programs. Currently, Uganda and Tanzania are in the early stages of the PCP-FMD. This review was undertaken to determine FMDV serotype distribution in Uganda and Tanzania between 2003 and 2015. The paper also presents the vaccine strains used in both countries for the same period viz avis the circulating topotypes. The review highlights four (O, A, SAT 1 and SAT 2) and five (O, A, SAT 1, SAT 2 and SAT 3) serotypes that occurred in Uganda and Tanzania respectively in the thirteen year period. Observations revealed that reported circulating serotypes O and A in the two countries belonged to similar topotypes, East African 2 (EA-2) and AFRICA respectively. The SAT 1 viruses in Tanzania belonged to topotype I and differed from the Ugandan SAT 1s that belonged to topotype IV. Similarly, the SAT 2s in both countries belonged to different topotypes: IV in Tanzania and I in Uganda. This review additionally, underscores the spatial distribution of FMDV serotypes in Uganda and Tanzania and highlights regions in both countries that had high serotype diversity. The paper recommends definitive disease diagnoses, molecular serotype characterisation and matched vaccination deployment for improved disease control.