Persistent chest pain predicts cardiovascular events in women without obstructive coronary artery disease: results from the NIH-NHLBI-sponsored Women's Ischaemia Syndrome Evaluation (WISE) study
Persistent chest pain predicts cardiovascular events in women without obstructive coronary artery disease: results from the NIH-NHLBI-sponsored Women's Ischaemia Syndrome Evaluation (WISE) study
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DOI：
10.1093/eurheartj/ehl040
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发表时间：
2006-06-01
影响因子：
39.3
通讯作者：
Merz, C. Noel Bairey
中科院分区：
文献类型：
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作者：
Johnson, B. Delia;Shaw, Leslee J.;Merz, C. Noel Bairey
目的是患有胸痛但没有阻塞性冠状动脉疾病（CAD）的女性患心血管（CV）事件的风险低，但多年来，一半的妇女仍有一半的胸痛。这项研究比较了持续性胸痛（PCHP）与没有PCHPMETHOD的女性的CV结局，结果我们研究了673名女性缺血综合症评估（WISE）参与者，患有胸痛的冠状动脉造影，可疑的心脏病学和至少在后续的1年年度。向上。 PCHP被定义为1年后自我报告的持续胸痛。在那一年之后发生的事件记录了中位5。2年。我们比较了有或没有阻塞性CAD的亚组中患有PCHP和没有PCHP的女性的CV事件发生率。中位年龄为58岁，有20％是少数族裔，有45％的人患有PCHP，39％的人患有阻塞性CAD。在没有CAD的女性中，患有PCHP的女性的复合简历事件发生率（p = 0.03），包括非致命性心肌梗死（P = 0.11），中风（P = 0.03），充血性心力衰竭（P = p = 0.38）和CV死亡（P = 0.73），与患有CAD的女性中没有PCHP的人相比，在有和没有的患者中，复合CV事件没有差异PCHP（p = 0.72）。怀疑心肌缺血的冠状动脉血管造影的妇女中的结论，没有阻塞性CAD的女性的PCHP预测CV不良的CV结果。这样的妇女可能会受益于其他评估和积极的风险因素修饰疗法。
Aims Women with chest pain but without obstructive coronary artery disease (CAD) are considered at low risk for cardiovascular (CV) events, but half continue to experience debilitating chest pain over many years. This study compared CV outcomes in women with persistent chest pain (PChP) vs. those without PChPMethods and results We studied 673 Women's Ischaemia Syndrome Evaluation (WISE) participants with chest pain undergoing coronary angiography for suspected myocardial ischaemia and at least 1 year of follow-up. PChP was defined as self-reported continuing chest pain after 1 year. Events occurring after that year were recorded for a median of 5.2 years. We compared CV event rates for women with and without PChP in subgroups with and without obstructive CAD. The median age was 58 years, 20% were racial minorities, 45% had PChP, 39% had obstructive CAD. Among women without CAD, those with PChP had more than twice the rate of composite CV events (P=0.03), that included non-fatal myocardial infarctions (P=0.11), strokes (P=0.03), congestive heart failure (P=0.38), and CV deaths (P=0.73), compared with those without PChP In women with CAD, there was no difference in composite CV events in those with and without PChP (P=0.72).Conclusion Among women undergoing coronary angiography for suspected myocardial ischaemia, PChP in women with no obstructive CAD predicted adverse CV outcomes. Such women might benefit from additional evaluation and aggressive risk factor modification therapy.