Myalgic Encephalomyelitis (ME), Chronic Fatigue Syndrome (CFS), and Chronic Fatigue (CF) are distinguished accurately: Results of supervised learning techniques applied on clinical and inflammatory data
Myalgic Encephalomyelitis (ME), Chronic Fatigue Syndrome (CFS), and Chronic Fatigue (CF) are distinguished accurately: Results of supervised learning techniques applied on clinical and inflammatory data
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DOI：
10.1016/j.psychres.2012.03.031
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发表时间：
2012-12-30
影响因子：
11.3
通讯作者：
Johnson, Cort
中科院分区：
文献类型：
--
作者：
Maes, Michael;Twisk, Frank N. M.;Johnson, Cort
肌痛性脑脊髓炎（Myalgic Encephalomyelitis， ME）、慢性疲劳综合征（Chronic Fatigue Syndrome， CFS）和慢性疲劳症（Chronic Fatigue， CF）的诊断分类存在很大争议。运动后不适（PEM）被强调为一个关键特征。本研究探讨CF和CFS是否有和没有PEM，是不同的诊断类别。采用Fukuda’s标准对144例慢性疲劳患者进行诊断，并对不符合Fukuda’s标准的CFS和CF患者进行鉴别。PEM是通过一个定义在0到6之间的刻度来评定的。将CFS患者分为PEM持续24 h以上（ME）和无PEM （CFS）两组。采用12项纤维肌痛和慢性疲劳综合征（FF）评定量表来衡量疾病的严重程度。血浆白细胞介素-1 （IL-1）、肿瘤坏死因子(TNF) α、溶菌酶和血清新蝶呤作为外部验证标准。使用疲劳、感染的主观感觉和PEM，我们发现ME、CFS和CF是不同的类别。与CFS患者相比，ME患者在注意力集中困难和主观感染体验方面的得分明显更高，IL-1、TNF α和neopterin的水平也更高。这些生物标志物在ME和CFS患者中明显高于CF患者。PEM高度负载于从数据集中减去的前两个因素，即。“萎靡-恶心”和“萎靡-痛觉过敏”。福田的标准足以区分ME/CFS和CF，但ME/CFS患者应细分为ME（伴PEM）和CFS（无PEM）。2012爱思唯尔爱尔兰有限公司版权所有。
There is much debate on the diagnostic classification of Myalgic Encephalomyelitis (ME), Chronic Fatigue Syndrome (CFS) and chronic fatigue (CF). Post-exertional malaise (PEM) is stressed as a key feature. This study examines whether CF and CFS, with and without PEM, are distinct diagnostic categories.Fukuda's criteria were used to diagnose 144 patients with chronic fatigue and identify patients with CFS and CF, i.e. those not fulfilling the Fukuda's criteria. PEM was rated by means of a scale with defined scale steps between 0 and 6. CFS patients were divided into those with PEM lasting more than 24 h (labeled: ME) and without PEM (labeled: CFS). The 12-item Fibromyalgia and Chronic Fatigue Syndrome (FF) Rating Scale was used to measure severity of illness. Plasma interleukin-1 (IL-1), tumor necrosis factor (TNF)alpha, and lysozyme, and serum neopterin were employed as external validating criteria.Using fatigue, a subjective feeling of infection and PEM we found that ME, CFS, and CF were distinct categories. Patients with ME had significantly higher scores on concentration difficulties and a subjective experience of infection, and higher levels of IL-1, TNF alpha, and neopterin than patients with CFS. These biomarkers were significantly higher in ME and CFS than in CF patients. PEM loaded highly on the first two factors subtracted from the data set, i.e. "malaise-sickness" and "malaise-hyperalgesia".Fukuda's criteria are adequate to make a distinction between ME/CFS and CF, but ME/CFS patients should be subdivided into ME (with PEM) and CFS (without PEM). (C) 2012 Elsevier Ireland Ltd. All rights reserved.