Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-κB activation
Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-κB activation
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DOI：
10.1016/s0014-5793(01)02414-0
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发表时间：
2001-05-11
期刊：
影响因子：
3.5
通讯作者：
Tschopp, J
中科院分区：
文献类型：
--
作者：
Gaide, O;Martinon, F;Tschopp, J
Bdl 10是从粘膜相关淋巴组织（MALT）B淋巴瘤中的断点鉴定的含有半胱天冬酶募集结构域（CARD）的蛋白质，其对于淋巴细胞中抗原受体介导的核因子κ B（NF-κ B）活化是必需的。我们发现了一个新的CARD蛋白和Bcl 10的相互作用伙伴，命名为Carma 1，Carma 1主要在淋巴细胞中表达，是膜相关鸟苷酸激酶家族的新成员。Carma 1通过其CARD基序结合Bcl 10，并诱导Bcl 10从细胞质易位到核周结构。此外，Carma 1的表达诱导Bcl 10的磷酸化和转录因子NF-κ B的激活。我们提出，Carma 1是一种新的Bct 10依赖性信号通路的T细胞，导致NF-κ B的激活的关键组成部分。(C)2001年欧洲生物化学学会联合会。由Elsevier Science B. V.出版，版权所有。
Bdl10, a caspase recruitment domain (CARD)containing protein identified from a breakpoint in mucosa-associated lymphoid tissue (MALT) B lymphomas, is essential for antigen-receptor-mediated nuclear factor kappaB (NF-kappaB) activation in lymphocytes. We have identified a novel CARD-containing protein and interaction partner of Bcl10, named Carma1, Carma1 is predominantly expressed in lymphocytes and represents a new member of the membrane-associated guanylate kinase family. Carma1 binds Bcl10 via its CARD motif and induces translocation of Bcl10 from the cytoplasm into perinuclear structures. Moreover, expression of Carma1 induces phosphorylation of Bcl10 and activation of the transcription factor NF-kappaB, We propose that Carma1 is a crucial component of a novel Bct10-dependent signaling pathway in T-cells that leads to tbe activation of NF-kappaB. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.