The induction of systemic and mucosal immune responses to antigen-adjuvant compositions administered into the skin: alterations in the migratory properties of dendritic cells appears to be important for stimulating mucosal immunity
The induction of systemic and mucosal immune responses to antigen-adjuvant compositions administered into the skin: alterations in the migratory properties of dendritic cells appears to be important for stimulating mucosal immunity
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DOI：
10.1016/s0264-410x(00)00059-1
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发表时间：
2000-06-01
期刊：
影响因子：
5.5
通讯作者：
Daynes, RA
中科院分区：
文献类型：
--
作者：
Enioutina, EY;Visic, D;Daynes, RA
描述了在皮内给药后能够诱导全身和普通粘膜免疫的各种疫苗佐剂制剂的性质。有效的粘膜佐剂，包括细菌毒素、环AMP的化学增强剂和维生素D3的活性形式，都具有促进树突状细胞在抗原诱导成熟后从皮肤迁移到派尔集合淋巴结的能力。我们的数据表明，皮肤树突状细胞可以作为有效的抗原呈递细胞诱导粘膜免疫反应，如果微环境条件进行适当的操纵后，他们的刺激抗原。(C)2000爱思唯尔科技有限公司版权所有。
The properties of various vaccine-adjuvant formulations that are capable of inducing both systemic and common mucosal immunity subsequent to their intradermal administration are described. Effective mucosal adjuvants, including bacterial toxins, chemical enhancers of cyclic AMP, and the active form of vitamin D3, all shared the ability to promote dendritic cell migration from the skin to Peyer's patches subsequent to antigen induced maturation. Our data suggests that skin dendritic cells may function as effective antigen presenting cells for the induction of mucosal immune responses, if microenvironmental conditions are appropriately manipulated subsequent to their stimulation by antigen. (C) 2000 Elsevier Science Ltd. All rights reserved.