Kaposi sarcoma-associated herpesvirus (KSHV): molecular biology and oncogenesis.

Kaposi sarcoma-associated herpesvirus (KSHV): molecular biology and oncogenesis.
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DOI:
10.1016/j.canlet.2009.07.004
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发表时间:
2010-03-28
期刊:
影响因子:
9.7
通讯作者:
Damania, Blossom
Damania, Blossom
中科院分区:
医学1区
文献类型:
--
作者:
Wen, Kwun Wah;Damania, Blossom

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Kaposi sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA herpesvirus belonging to the gammaherpesvirinae subfamily. KSHV has been associated with the development of three neoplastic diseases: Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). In this review, we discuss the three KSHV-associated malignancies, KSHV genome, latent and lytic aspects of the viral lifecycle, putative viral oncogenes, as well as therapeutic regimens used for the treatment of KS, PEL, and MCD.
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