Type 2 Innate Lymphoid Cells: Protectors in Type 2 Diabetes.
Type 2 Innate Lymphoid Cells: Protectors in Type 2 Diabetes.
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DOI：
10.3389/fimmu.2021.727008
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发表时间：
2021
影响因子：
7.3
通讯作者：
Akbari O
中科院分区：
文献类型：
--
作者：
Painter JD;Akbari O
2 型先天淋巴细胞 (ILC2) 是 Th2 细胞的先天对应物，在多种组织的体内平衡维持中发挥着重要作用。 ILC2 不表达特定的抗原受体，而是对外部刺激（例如损伤释放的警报素）做出反应。这些细胞有助于控制脂肪组织炎症的微妙平衡，这是代谢结果的决定因素。 ILC2 通过对组织稳态的保护作用在 2 型糖尿病 (T2DM) 的发病机制中发挥关键作用。驻留脂肪细胞和 ILC2 之间会发生各种串扰，每种相互作用在控制这种平衡方面都发挥着关键作用。 ILC2 效应器功能与脂肪组织褐变增加和抗炎免疫特征相关。 ILC2 群体的运输和维持对于组织稳态至关重要。代谢环境和能量来源除了影响 ILC2 与常驻细胞类型的相互作用外，还显着影响 ILC2 的数量和功能。 ILC2 对代谢环境变化的反应是疾病严重程度的明确决定因素。通过关键免疫细胞治疗代谢不稳定的根源为调节系统稳态和 T2DM 新疗法提供了明确的途径。
Type 2 innate lymphoid cells (ILC2) are the innate counterparts of Th2 cells and are critically involved in the maintenance of homeostasis in a variety of tissues. Instead of expressing specific antigen receptors, ILC2s respond to external stimuli such as alarmins released from damage. These cells help control the delicate balance of inflammation in adipose tissue, which is a determinant of metabolic outcome. ILC2s play a key role in the pathogenesis of type 2 diabetes mellitus (T2DM) through their protective effects on tissue homeostasis. A variety of crosstalk takes place between resident adipose cells and ILC2s, with each interaction playing a key role in controlling this balance. ILC2 effector function is associated with increased browning of adipose tissue and an anti-inflammatory immune profile. Trafficking and maintenance of ILC2 populations are critical for tissue homeostasis. The metabolic environment and energy source significantly affect the number and function of ILC2s in addition to affecting their interactions with resident cell types. How ILC2s react to changes in the metabolic environment is a clear determinant of the severity of disease. Treating sources of metabolic instability via critical immune cells provides a clear avenue for modulation of systemic homeostasis and new treatments of T2DM.
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影响因子：
7.3
作者：
Babaei, Rohollah;Schuster, Maximilian;Vegiopoulos, Alexandros
通讯作者：
Vegiopoulos, Alexandros
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
30.5
作者：
Bernink, Jochem H.;Ohne, Yoichiro;Humbles, Alison A.
通讯作者：
Humbles, Alison A.
影响因子：
7
作者：
Boisson-Dupuis S;Kong XF;Okada S;Cypowyj S;Puel A;Abel L;Casanova JL
通讯作者：
Casanova JL
影响因子：
64.8
作者：
Cardoso V;Chesné J;Ribeiro H;García-Cassani B;Carvalho T;Bouchery T;Shah K;Barbosa-Morais NL;Harris N;Veiga-Fernandes H
通讯作者：
Veiga-Fernandes H