Novel hybrid Artificial Liver using Hepatocyte Organoids
Novel hybrid Artificial Liver using Hepatocyte Organoids
复制标题
使用肝细胞类器官的新型混合人工肝
DOI：
10.1177/039139880202500201
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
K. Nakazawa
中科院分区：
文献类型：
--
作者：
K. Funatsu;K. Nakazawa
肝细胞可为可逆性肝衰竭患者提供临时肝脏支持，并可作为肝移植的桥梁。这样的装置应该去除有毒物质以及提供有用的生物化合物。然而，为了在临床上有用，它必须能够在合理的时间内有效地发挥作用。为了开发HAL，需要适当的细胞来源（猪或人），以及建立能够表达足够肝功能的细胞培养技术。设计生物反应器（人工肝模块）和开发体外循环装置是必要的。从工程的角度来看，HAL可以被视为一种微型工厂，它使用肝细胞作为生物催化剂，其模型类似于大型石化工厂的缩小版本。
hepatocytes may provide temporary liver support for patients with reversible hepatic failure and function as a bridge for liver transplantation. Such a device should remove toxic substances as well as supply useful biological compounds. To be useful clinically, however, it must be able to function effectively for a reasonable period of time. For the development of a HAL an appropriate cell source (pig or human) is required, as well as establishing a cell culture technique capable of expressing adequate hepatic function. It is necessary to design a bioreactor (artificial liver module) and to develop an extracorporeal circulation device. From an engineering viewpoint, a HAL can be viewed as a micro-plant that uses hepatocytes as biocatalysts in a model resembling a scaled down version of a large petrochemical plant.
使用肝细胞类器官的混合人工肝
DOI：
--
发表时间：
2004
期刊：
Therapeutics & Engineering Vol.16, No.3
影响因子：
--
作者：
Y. Yoshihara;H. Sugawara;H. lto;K. Okada;and K. Masu;K.Nakazawa et al.
通讯作者：
K.Nakazawa et al.