Vitamin D Deficiency in Relation to the Risk of Metabolic Syndrome in Middle-Aged and Elderly Patients with Type 2 Diabetes Mellitus.
Vitamin D Deficiency in Relation to the Risk of Metabolic Syndrome in Middle-Aged and Elderly Patients with Type 2 Diabetes Mellitus.
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DOI：
10.3177/jnsv.62.213
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发表时间：
2016
影响因子：
1.6
通讯作者：
Guotao Pan;Jiandong Guo;Shaolin Mei;Meng-xi Zhang;Zhi-yong Hu;Chong-Ke Zhong;C. Zeng;Xiao-hong Liu;Q. Ma;Bing-yan Li;L. Qin;Zeng-li Zhang
中科院分区：
文献类型：
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作者：
Guotao Pan;Jiandong Guo;Shaolin Mei;Meng-xi Zhang;Zhi-yong Hu;Chong-Ke Zhong;C. Zeng;Xiao-hong Liu;Q. Ma;Bing-yan Li;L. Qin;Zeng-li Zhang
维生素 D 缺乏症在世界各地都很普遍，而中国的维生素 D 膳食摄入量却很低。在本研究中，我们旨在确定维生素 D 缺乏是否与中国 50 岁以上 2 型糖尿病 (T2DM) 患者代谢综合征 (MetS) 风险增加相关。对来自浙江的 270 名 50 岁以上 T2DM 患者的横截面样本进行了血清 25-羟基维生素 D [25(OH)D] 浓度的测量。收集了人口特征、人体测量学和其他变量的数据。血清25(OH)D平均值为22.93 ng/mL，维生素D缺乏和不足的比例分别为43.71%和39.63%。患有 MetS 的受试者的血清 25(OH)D 浓度显着低于无 MetS 的受试者（21.74 vs 24.96 ng/mL，p=0.001），并且根据血清 25(OH)D 浓度的三分位数，MetS 的患病率显着增加。调整多变量因素后，BMI≥24 kg/m2组中较低血清25(OH)D浓度的不利影响显着（OR：3.26，95% CI：1.03-7.34；p=0.044），而血清25（OH）D浓度每降低10 ng/mL，MetS OR的变化为2.03（95% CI： 1.10-3.79）。这些结果提示血清25(OH)D缺乏可能是中国2型糖尿病患者尤其是BMI≥24 kg/m2的T2DM患者发生MetS的危险因素。面临的挑战是确定维生素 D 的作用机制，以建议补充维生素 D，从而降低 MetS 和进展为 T2DM 的风险。
Vitamin D deficiency is highly prevalent all over the world and dietary intakes of vitamin D are very low in China. In this study we aimed to determine whether vitamin D deficiency is associated with increased risk of metabolic syndrome (MetS) among Chinese type 2 diabetes mellitus (T2DM) patients aged over 50 y. Serum 25-hydroxyvitamin D [25(OH)D] concentrations were measured in a cross-sectional sample of 270 T2DM patients aged over 50 y from Zhejiang. Data on demographic characteristics, anthropometry and other variables were collected. The mean of serum 25(OH)D was 22.93 ng/mL, and percentages of vitamin D deficiency and insufficiency were 43.71% and 39.63%, respectively. Serum 25(OH)D concentrations were significantly lower in subjects with MetS than in those without MetS (21.74 vs 24.96 ng/mL, p=0.001), and the prevalence of MetS significantly increased according to tertiles of serum 25(OH)D concentrations. After adjusting for multivariate factors, the adverse effect of lower serum 25(OH)D concentrations was significant (OR: 3.26, 95% CI: 1.03-7.34; p=0.044) in the group with BMI≥24 kg/m2 while the change in OR of MetS for each 10 ng/mL decrease in the serum 25(OH)D concentrations was 2.03 (95% CI: 1.10-3.79). These results suggest that serum 25(OH)D deficiency may be a risk factor of MetS among Chinese type 2 diabetic patients, especially in the T2DM with BMI≥24 kg/m2. The challenge is determining the mechanisms of vitamin D action for recommendation of vitamin D supplementation that reduces the risks of MetS and progression to T2DM.