FECAL WEIGHT, COLON CANCER RISK, AND DIETARY-INTAKE OF NONSTARCH POLYSACCHARIDES (DIETARY FIBER)
FECAL WEIGHT, COLON CANCER RISK, AND DIETARY-INTAKE OF NONSTARCH POLYSACCHARIDES (DIETARY FIBER)
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DOI：
10.1016/0016-5085(92)91435-7
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发表时间：
1992-12-01
期刊：
影响因子：
29.4
通讯作者：
EASTWOOD, MA
中科院分区：
文献类型：
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作者：
CUMMINGS, JH;BINGHAM, SA;EASTWOOD, MA
粪便重量低和排便时间慢被认为与肠癌风险有关，但很少有公开发表的数据定义不同社区的排便习惯。因此，为了更准确地定义这种风险，我们从12个国家的20个人群中收集了关于大便重量的数据，并量化了大便重量与膳食中非淀粉多糖(NSP)(膳食纤维)摄入量之间的关系。在220名健康的英国成年人中，每天仔细收集粪便的中位数为106克/天(男性，104克/天；女性，99克/天；P=0.02)，全肠道通过时间为60小时(男性，55小时；女性，72小时；P=0.05)；17%的女性，但只有1%的男性每天排出50克大便。来自世界其他人群的数据显示，平均粪便重量在72至470g/天之间，与结肠癌风险呈负相关(r=−0.78)。对11项研究的Meta分析表明，纤维摄入量与平均每日粪便重量之间存在显著相关性(r=0.84)，其中26组人(n=206)的每日粪便重量在已知NSP含量的对照饮食中被准确测量。许多西方人的粪便重量很低(每天80-120克)，这与结肠癌风险增加有关。日粮中添加非淀粉多糖类物质可增加粪便产量。以高NSP摄入量为特征的饮食(约18克/天)与每天150克的粪便重量有关，应该会降低患肠癌的风险。
Low fecal weight and slow bowel transit time are thought to be associated with bowel cancer risk, but few published data defining bowel habits in different communities exist. Therefore, data on stool weight were collected from 20 populations in 12 countries to define this risk more accurately, and the relationship between stool weight and dietary intake of nonstarch polysaccharides (NSP) (dietary fiber) was quantified. In 220 healthy U.K. adults undertaking careful fecal collections, median daily stool weight was 106 g/day (men, 104 g/day; women, 99 g/day;P= 0.02) and whole-gut transit time was 60 hours (men, 55 hours; women, 72 hours;P= 0.05); 17% of women, but only 1% of men, passed < 50 g stool/day. Data from other populations of the world show average stool weight to vary from 72 to 470 g/day and to be inversely related to colon cancer risk (r= −0.78). Meta-analysis of 11 studies in which daily fecal weight was measured accurately in 26 groups of people (n = 206) on controlled diets of known NSP content shows a significant correlation between fiber intake and mean daily stool weight (r= 0.84). Stool weight in many Westernized populations is low (80–120 g/day), and this is associated with increased colon cancer risk. Fecal output is increased by dietary NSP. Diets characterized by high NSP intake (approximately 18 g/day) are associated with stool weights of 150 g/day and should reduce the risk of bowel cancer.