Selective ion sensing with high resolution large area graphene field effect transistor arrays
Selective ion sensing with high resolution large area graphene field effect transistor arrays
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DOI：
10.1038/s41467-020-16979-y
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发表时间：
2020-06-26
影响因子：
16.6
通讯作者：
Szkopek, Thomas
中科院分区：
文献类型：
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作者：
Fakih, Ibrahim;Durnan, Oliver;Szkopek, Thomas
利用现有的色谱、分光光度和电位技术，实时、高分辨率、同时测量多种离子种类是具有挑战性的。电位型离子传感器在分辨率和选择性方面都存在局限性。在此，我们开发了晶圆级石墨烯晶体管技术来克服这些限制。大面积石墨烯是用于高分辨率离子敏感场效应晶体管（ISFET）的理想材料，同时与传统半导体相比能够实现容易的制造。我们将ISFET发展成阵列，并应用Nikolskiii-Eisenman分析来解释交叉敏感性，从而实现高选择性。我们实验证明实时，同时浓度测量的K+，Na+，N-4（+），NO3-，SO 42-，HPO 42-和Cl-的分辨率类似于2 × 10（-3）对数浓度单位。该阵列实现了+/- 0.05 log浓度的准确度。最后，我们展示了实时离子浓度测量在水族馆与lemnoideae浮萍超过三个星期，其中水生生物的矿物质吸收，可以观察到在其生长过程中。
Real-time, high resolution, simultaneous measurement of multiple ionic species is challenging with existing chromatographic, spectrophotometric and potentiometric techniques. Potentiometric ion sensors exhibit limitations in both resolution and selectivity. Herein, we develop wafer scale graphene transistor technology for overcoming these limitations. Large area graphene is an ideal material for high resolution ion sensitive field effect transistors (ISFETs), while simultaneously enabling facile fabrication as compared to conventional semiconductors. We develop the ISFETs into an array and apply Nikolskii- Eisenman analysis to account for cross-sensitivity and thereby achieve high selectivity. We experimentally demonstrate real-time, simultaneous concentration measurement of K+, Na+, N-4(+), NO3-, SO42-, HPO42- and Cl- with a resolution of similar to 2 x 10(-3) log concentration units. The array achieves an accuracy of +/- 0.05 log concentration. Finally, we demonstrate real-time ion concentration measurement in an aquarium with lemnoideae lemna over three weeks, where mineral uptake by aquatic organisms can be observed during their growth.