Role of in vivo proton magnetic resonance spectroscopy in the diagnosis and management of brain abscesses
Role of in vivo proton magnetic resonance spectroscopy in the diagnosis and management of brain abscesses
复制标题
DOI：
10.1097/00006123-199801000-00008
复制
发表时间：
1998-01-01
期刊：
影响因子：
4.8
通讯作者：
Husain, M
中科院分区：
文献类型：
--
作者：
Dev, R;Gupta, RK;Husain, M
目的：在体内质子磁共振波谱进行了24例化脓性脑脓肿，检查频谱模式的一致性，并观察代谢物与treatment.METHODS的变化：局部质子谱获得4至8毫升体积的脓肿，使用刺激回波采集模式和自旋回波序列。22例患者接受了手术和药物联合治疗，2例患者接受了保守治疗。高分辨率磁共振波谱进行了15个样本的肿瘤从这些患者，以确认在体内看到的共振分配。抽吸后的研究进行了12例合并内科和外科治疗和2例患者治疗medicinal.RESULTS：乳酸和氨基酸被认为是所有患者的光谱，无论时间的光谱后，合并内科和外科治疗。乙酸和丙酮酸在联合治疗1周后消失。结论：脑水肿的光谱模式是一致的和特异性的，可以帮助无创性诊断水肿。对联合治疗的反应可以通过显示系列光谱研究中代谢物模式的变化来监测。
OBJECTIVE: In vivo proton magnetic resonance spectroscopy was performed for 24 patients with pyogenic brain abscesses, to examine the consistency of the spectral patterns and to observe the changes in metabolites with treatment.METHODS: Localized proton spectra were obtained from 4- to 8-ml volumes in the abscesses, using stimulated echo acquisition mode and spin echo sequences. Twenty-two patients were treated with combined surgical and medical therapy, and two patients were treated conservatively. High-resolution magnetic resonance spectroscopy was performed for 15 samples of abscesses obtained from these patients, to confirm the assignments of resonances seen in vivo. Postaspiration studies were performed for 12 patients treated with combined medical and surgical therapy and 2 patients treated medically.RESULTS: Lactate and amino acids were seen in spectra for all patients, irrespective of the time of spectroscopy after the onset of combined medical and surgical therapy. Acetate and pyruvate disappeared after 1 week of combined treatment.CONCLUSION: It was concluded that spectral patterns for brain abscesses are consistent and specific and can assist in the noninvasive diagnosis of abscesses. Responses to combined treatment could be monitored by showing the changes in metabolite patterns in serial spectroscopic studies.