Phorbol esters stimulate the potassium-induced release of cholecystokinin from slices of cerebral cortex, caudato-putamen and hippocampus incubated in vitro.
Phorbol esters stimulate the potassium-induced release of cholecystokinin from slices of cerebral cortex, caudato-putamen and hippocampus incubated in vitro.
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DOI：
10.1016/s0006-291x(88)81233-6
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发表时间：
1988-05
影响因子：
3.1
通讯作者：
L. Allard;M. Beinfeld
中科院分区：
文献类型：
--
作者：
L. Allard;M. Beinfeld
将尾壳核、大脑皮层和海马切片与佛波醇 12,13-二丁酸酯 (PDB) 或佛波醇 12-肉豆蔻酸酯 13-乙酸酯 (PMA) 一起孵育 5 至 15 分钟，可使钾诱发的胆囊收缩素 (CCK) 释放量从对照的 139% 增加至 296%。无活性的 4α 佛波醇和 4α PDB 不会改变 CCK 的释放。测试的活性或非活性佛波醇均未改变基础 CCK 释放。这些结果表明不同脑区CCK释放的调节可能存在相似性。尽管调节 CCK 释放的生理因素在这些组织中可能不同，但它们的共同作用可能是由肌醇磷脂周转产物介导的。
Incubation of slices of caudato-putamen, cerebral cortex and hippocampus for 5 to 15 minutes with phorbol 12,13-dibutyrate (PDB) or phorbol 12-myristate 13-acetate (PMA) increased potassium evoked cholecystokinin (CCK) release from 139% to 296% of control. The inactive 4 α phorbol and 4 α PDB did not alter CCK release. None of the active or inactive phorbols tested altered basal CCK release. These results suggest that there may be similarities in the regulation of CCK release in different brain regions. Although the physiological factors which regulate CCK release may differ in these tissues, it is possible that their common action is mediated by the products of inositol phospholipid turnover.