Microenvironmental regulation of therapeutic response in cancer.
Microenvironmental regulation of therapeutic response in cancer.
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DOI：
10.1016/j.tcb.2014.11.006
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发表时间：
2015-04
影响因子：
19
通讯作者：
Joyce JA
中科院分区：
文献类型：
--
作者：
Klemm F;Joyce JA
肿瘤微环境（tumor microenvironment， TME）不仅在肿瘤的进展和转移过程中起着关键作用，而且对治疗效果有着深远的影响。在微环境介导的耐药情况下，这可能涉及内在反应，包括预先存在的结构元件和信号网络的共同选择，或肿瘤基质在治疗损伤后的适应性反应。另外，在其他情况下，TME具有多方面的能力来提高治疗效果。本文回顾了我们对TME在癌症治疗中的作用的理解的最新进展，并讨论了可能适用于治疗干预的关键概念。
The tumor microenvironment (TME) not only plays a pivotal role during cancer progression and metastasis but also has profound effects on therapeutic efficacy. In the case of microenvironment-mediated resistance this can involve an intrinsic response, including the co-option of pre-existing structural elements and signaling networks, or an adaptive response of the tumor stroma following the therapeutic insult. Alternatively, in other contexts, the TME has a multifaceted ability to enhance therapeutic efficacy. This review examines recent advances in our understanding of the contribution of the TME during cancer therapy and discusses key concepts that may be amenable to therapeutic intervention.