Stem Cell Transplantation in Cardiovascular Disease: An Update
Stem Cell Transplantation in Cardiovascular Disease: An Update
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DOI：
10.1177/147323001204000301
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发表时间：
2012-06
影响因子：
1.6
通讯作者：
M. Teng;Zhaohua Geng;Lan Huang;Xiaohui Zhao
中科院分区：
文献类型：
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作者：
M. Teng;Zhaohua Geng;Lan Huang;Xiaohui Zhao
尽管开发了新的治疗策略，心血管疾病仍然是全球发病率和死亡率的主要原因。许多1期和2期临床试验已经报道了干细胞移植的安全性、可行性和前景，但最佳细胞类型、输注时机、细胞剂量和给药途径仍有待确定。本文综述了各种临床研究的结果，并讨论了干细胞疗法在心血管疾病中所面临的挑战。
Despite the development of novel therapeutic strategies, cardiovascular diseases remain the main cause of morbidity and mortality worldwide. Many phase 1 and 2 clinical trials have reported the safety, feasibility and promising potential of stem cell transplantation, however, the optimal cell types, timing of infusion, cell dosage and routes of administration remain to be determined. This paper reviews the findings of various clinical studies and discusses the challenges facing the delivery of stem cell therapy in cardiovascular diseases.