[Research Progress of m6A-Methylation in Acute Leukemia-Review].
[Research Progress of m6A-Methylation in Acute Leukemia-Review].
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DOI：
10.19746/j.cnki.issn.1009-2137.2019.06.050
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发表时间：
2019-12-01
期刊：
影响因子：
--
通讯作者：
Yu, Liang
中科院分区：
文献类型：
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作者：
Chen, Qiu-Ni;Chen, Yue;Yu, Liang
目的：表观遗传异常在恶性血液病尤其是急性白血病的发病机制中起重要作用。与DNA甲基化和组蛋白修饰类似，RNA甲基化是另一种重要的表观遗传修饰。m6A甲基化是最普遍和最广泛研究的RNA甲基化之一。m6A甲基化参与许多生物学和病理学过程。近年来研究发现m6A甲基化参与了AL的发生、发展及耐药，本文就m6A甲基化在AL中的研究进展作一综述。
OBJECTIVE: Epigenetic abnormalities play an important role in the pathogenesis of hematological malignancies, especially acute leukemia (AL). Similar to DNA methylation and histone modifications, RNA methylation is another important epigenetic modification. m6A methylation is one of the most prevalent and extensively studied RNA methylation. m6A methylation is involved in many biological and pathological process. Recent studies have found that m6A methylation is involved in the occurrence, development and drug-resistance of AL. This review focuses on the research progress of m6A methylation in AL.