Anaplastic Thyroid Carcinoma: Cytomorphologic Features on Fine-Needle Aspiration and Associated Diagnostic Challenges.
Anaplastic Thyroid Carcinoma: Cytomorphologic Features on Fine-Needle Aspiration and Associated Diagnostic Challenges.
复制标题
甲状腺未分化癌：细针抽吸的细胞形态学特征及相关诊断挑战。
DOI：
10.1093/ajcp/aqab159
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发表时间：
2022
影响因子：
3.5
通讯作者：
Gilani,SyedM
中科院分区：
文献类型：
--
作者：
Podany,Peter;Abi-Raad,Rita;Barbieri,Andrea;Garritano,James;Prasad,ManjuL;Cai,Guoping;Adeniran,AdebowaleJ;Gilani,SyedM
目的：甲状腺未分化癌（ATC）是一种侵袭性恶性肿瘤，早期诊断，通常辅以细针穿刺（FNA），是改善患者预后的关键。虽然目前的文献描述了一些细胞学特征（CFs）的这个实体，一个全面的检查CFs尚未performed.MethodsWe回顾性地搜索我们的电子数据库ATC病例与可用的幻灯片之间的2008年1月和2019年12月。病例进行了检查，22 CF和比较与对照组分化型甲状腺carcinoma.ResultsA共18例ATC符合我们的纳入标准。大多数病例表现为中度至高度细胞化（83%）和上皮样细胞形态学（83%）。结构主要包括肿瘤细胞群/簇（56%）或单个肿瘤细胞（44%）。其他CF如下：核增大（100%）、核拥挤（89%）、核膜不规则（100%）、多核肿瘤细胞（33%）和背景急性炎症细胞（50%）。的CF检查，ATC和对照组之间的统计学显着差异被发现在以下方面：核多形性，粗/成团染色质，macronucleoli，凋亡，necrosis.ConclusionsIdentification的关键CF FNA加上临床病史的艾滋病ATC的诊断，并有助于区分它从其他模仿者。
ObjectivesAnaplastic thyroid carcinoma (ATC) is an aggressive malignancy, and early diagnosis, often aided by fine-needle aspiration (FNA), is key to improving patient prognosis. While the current literature describes some of the cytologic features (CFs) of this entity, a comprehensive examination of the CFs has not yet been performed.MethodsWe retrospectively searched our electronic database for ATC cases with available slides between January 2008 and December 2019. Cases were examined for 22 CFs and compared with a control group of differentiated thyroid carcinoma.ResultsA total of 18 ATC cases meeting our inclusion criteria were identified. Most cases showed moderate to high cellularity (83%) and epithelioid cytomorphology (83%). Architecture included either predominantly groups/clusters of tumor cells (56%) or single tumor cells (44%). The other CFs were as follows: nuclear enlargement (100%), nuclear crowding (89%), nuclear membrane irregularities (100%), multinucleated tumor cells (33%), and background acute inflammatory cells (50%). Of the CFs examined, statistically significant differences between ATC and the control groups were found in the following: nuclear pleomorphism, coarse/clumped chromatin, macronucleoli, apoptosis, and necrosis.ConclusionsIdentification of key CFs in FNA coupled with the clinical history aids in the diagnosis of ATC and helps distinguish it from other mimickers.