The taste of the pandemic-contemporary review on the current state of research on gustation in coronavirus disease 2019 (COVID-19).
The taste of the pandemic-contemporary review on the current state of research on gustation in coronavirus disease 2019 (COVID-19).
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DOI：
10.1002/alr.22902
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发表时间：
2022-03
影响因子：
6.4
通讯作者：
Hummel T
中科院分区：
文献类型：
--
作者：
Hintschich CA;Niv MY;Hummel T
主观感知的味觉受损是2019冠状病毒病（COVID-19）的常见和独特症状。大型Meta分析在大约50%的病例中发现了这种症状。然而，这种高患病率并没有得到盲法和经验证的心理物理味觉测试的支持，该测试显示高达26%的患者的患病率要低得多。这种差异可能是由于误解受损的鼻后嗅觉味觉功能障碍。此外，我们假设COVID-19相关的嗅觉减退与味觉功能的下降有关，就像在不同来源的嗅觉减退中发现的那样。这种间接机制将基于化学感觉之间的中枢神经相互放大，这在COVID-19相关的嗅觉丧失中失败。然而，还需要进一步研究严重急性呼吸综合征-冠状病毒-2（SARS-CoV-2）如何直接损害味觉通路及其主观感知。
Subjectively perceived impairment of taste is a common and distinct symptom of coronavirus disease 2019 (COVID‐19). Large meta‐analyses identified this symptom in approximately 50% of cases. However, this high prevalence is not supported by blinded and validated psychophysical gustatory testing, which showed a much lower prevalence in up to 26% of patients. This discrepancy may be due to misinterpretation of impaired retronasal olfaction as gustatory dysfunction. In addition, we hypothesized that COVID‐19–associated hyposmia is involved in the decrease of gustatory function, as found for hyposmia of different origin. This indirect mechanism would be based on the central‐nervous mutual amplification between the chemical senses, which fails in COVID‐19–associated olfactory loss. However, further research is necessary on how severe acute respiratory syndrome‐coronavirus‐2 (SARS‐CoV‐2) may directly impair the gustatory pathway as well as its subjective perception.
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