MELATONIN SHIFTS HUMAN CIRCADIAN-RHYTHMS ACCORDING TO A PHASE RESPONSE CURVE
MELATONIN SHIFTS HUMAN CIRCADIAN-RHYTHMS ACCORDING TO A PHASE RESPONSE CURVE
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DOI：
10.3109/07420529209064550
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发表时间：
1992-10-01
影响因子：
2.8
通讯作者：
SACK, RL
中科院分区：
文献类型：
--
作者：
LEWY, AJ;AHMED, S;SACK, RL
一种生理剂量的口服褪黑素会根据一条相位-反应曲线(PRC)改变人体的昼夜节律，该曲线在光照下几乎与PrC相反：早上给药时褪黑素会延迟昼夜节律，下午或傍晚时会提前。人类褪黑素PRC为使用褪黑素治疗昼夜节律睡眠和情绪障碍，以及对轮班工作和穿越子午线的航空旅行的适应不良提供了关键信息。人类褪黑激素PRC也提供了迄今为止最有力的证据，证明了内源性褪黑素的功能及其在光-暗循环中增强昼夜节律的夹带的光抑制作用。
A physiological dose of orally administered melatonin shifts circadian rhythms in humans according to a phase-response curve (PRC) that is nearly opposite in phase with the PRCs for light exposure: melatonin delays circadian rhythms when administered in the morning and advances them when administered in the afternoon or early evening. The human melatonin PRC provides critical information for using melatonin to treat circadian phase sleep and mood disorders, as well as maladaptation to shift work and transmeridional air travel. The human melatonin PRC also provides the strongest evidence to date for a function of endogenous melatonin and its suppression by light in augmenting entrainment of circadian rhythms by the light-dark cycle.