Quality of life in atrial fibrillation: The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study
Quality of life in atrial fibrillation: The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study
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DOI：
10.1016/j.ahj.2004.03.065
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发表时间：
2005-01-01
影响因子：
4.8
通讯作者：
Jenkins, LS
中科院分区：
文献类型：
--
作者：
Jenkins, LS
目的AFFIRM研究中预先指定的子研究的目的是，在随机分配到频率控制或节律控制的房颤（AF）患者中，未发现生存率或事件发生率的差异，是为了检验零假设，即生活质量（QoL）与AF的频率与节律控制治疗策略相等。随机选择的AFFIRM研究中心招募AFFIRM患者进行QoL子研究。QoL评估中使用的工具为（1）感知健康;（2）Cantril生命阶梯;（3）简表36调查;（4）QoL指数;（5）症状自评量表：频率和严重程度。数据收集在基线，2个月，12个月，每年，数据报告通过4年的follow-up.Results的AFFIRM生活质量患者（n = 716）的基线特征一般相似的AFFIRM患者的休息。在所有时间点，心率和节律控制分配组的生活质量评分相似。无论实际的节奏是窦性或AF的生活质量分数是相似的。分数从基线增加到随后的时间点类似的两个group.Conclusions率和节奏控制治疗策略之间的生活质量是可比的。此外，窦性心律与房颤患者的生活质量相似。通过恢复窦性心律改善生活质量的尝试通常不会成功。
Objective The objective of this prespecified substudy of the AFFIRM study, in which no differences in survival or event rates were found in patients with atrial fibrillation (AF) randomized to either rate control or rhythm control, was to test the null hypothesis that quality of life (QoL) is equal with rate- versus rhythm-control treatment strategies in AF.Methods Fifty-six (25%) of AFFIRM sites were randomly selected to recruit AFFIRM patients for the QoL substudy. Instruments used in the QoL assessment were (1) Perceived Health; (2) the Cantril Ladder of Life; (3) the Short Form 36 survey; (4) the QoL Index; and (5) the Symptom Checklist: Frequency and Severity. Data were collected at baseline, 2 months, 12 months, and annually; data are reported through 4 years of follow-up.Results Baseline characteristics of the AFFIRM QoL patients (n = 716) were generally similar to those of the rest of AFFIRM patients. Quality-of-life scores were similar in rate- and rhythm-control assignment groups at all time points. Quality-of life scores were similar whether the actual rhythm was sinus or AF. Scores increased from baseline to subsequent time points similarly for both groups; these improvements were not additive over time.Conclusions Quality of life was comparable between rate- and rhythm-control treatment strategies. In addition, QoL was similar with sinus rhythm versus AF. Attempts to improve QoL by restoring sinus rhythm will usually be unsuccessful.