Effects of artemisinin derivatives on malaria transmissibility
Effects of artemisinin derivatives on malaria transmissibility
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DOI：
10.1016/s0140-6736(96)91488-9
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发表时间：
1996-06-15
期刊：
影响因子：
168.9
通讯作者：
White, NJ
中科院分区：
文献类型：
--
作者：
Price, RN;Nosten, F;White, NJ
背景在泰国西部边境，甲氟喹治疗恶性疟疾的疗效下降，而配子体携带率增加，这表明这些耐药感染的传播性增加。我们比较了下列抗疟疾药物与随后的恶性疟原虫配子体携带的关系：甲氟喹、氟虫氨酸、奎宁和青蒿素衍生物。方法1990-1995年间，我们在一系列前瞻性研究中评估了配子细胞症。在泰国西部边境的一片疟疾丘陵森林地区，5193名成人和儿童患有急性无并发症的恶性疟疾，在4周(1990-93)或9周(1993-95)的随访期内进行了每周厚、薄血片寄生虫计数，计算配子体阳性率和人配子周(PGW)率以衡量配子携带和传递潜能。在原发恶性疟原虫感染中，甲氟喹治疗后配子体携带率显着高于青蒿素(PGW 34)治疗后。1[95%可信区间25.2-42。9]VS 3.9[1.9胜5负。9]每1000人周；相对风险8。0[41-156]；p
Background On the western border of Thailand the efficacy of mefloquine in the treatment of falciparum malaria has declined while gametocyte carriage rates have increased, which suggests increased transmissibility of these resistant infections. We compared the following antimalarial drugs in relation to subsequent Plasmodium falciparum gametocyte carriage: mefloquine, halofantrine, quinine, and the artemisinin derivatives.Methods Between 1990 and 1995 we assessed gametocytaemia in a series of prospective studies of antimalarial drug treatment in 5193 adults and children with acute uncomplicated falciparum malaria in an area of malarious hill forest on the western border of Thailand, Weekly parasite counts from thick and thin blood films were done during the 4-week (1990-93) or 9-week (1993-95) follow-up period, Gametocyte positivity rates and person gametocyte week (PGW) rates were calculated to measure gametocyte carriage and transmission potential.Findings In primary P falciparum infections the gametocyte carriage rate was significantly higher after treatment with mefloquine than after treatment with the artemisinin (PGW 34 . 1 [95% CI 25 . 2-42 . 9] vs 3 . 9 [1 . 9-5 . 9] per 1000 person weeks; relative risk 8 . 0 [41-156]; p