Metabolism of estrone and estradiol-17 in sheep.
Metabolism of estrone and estradiol-17 in sheep.
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绵羊体内雌酮和雌二醇 17 的代谢。
DOI：
10.1210/endo-91-6-1450
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发表时间：
1972
期刊：
影响因子：
4.8
通讯作者：
C. Longcope
中科院分区：
文献类型：
--
作者：
N. Kazama;C. Longcope
采用恒速输注法和动脉采血法测定了雌酮（E1）和雌二醇-17 β（E2β）在绵羊体内的代谢清除率和相互转化率。在6只母羊中，E1的平均（±SEM）MCR为91 ± 3 1血液/天/kg，平均值（95%置信限）[ρ]1，β β，β为0.138（0.102-0.187）。4只母羊E2β的平均MCR为87 α 71血/天/kg，平均[ρ]1，β β，β为0.156（0.11 ~ 0.221）。这些MCR和[ρ]β、β值之间无显著差异。对于这两种类固醇，似乎存在高度的内脏外代谢。还测量了每种类固醇向雌二醇-17 α的转化，结果表明，雌二醇-17 β向雌二醇-17 α的转化在一定程度上通过不涉及游离雌酮血池的途径发生。（内分泌学91：1450，1972）
The metabolic clearance and interconversion rates of estrone (E1) and estradiol-17β (E2β) have been measured in sheep using constant infusion techniques and sampling arterial blood. In 6 ewes the mean (±SEM) MCR for E1 is 91 ± 3 1 of blood/day/kg and the mean (95% confidence limits) [ρ]1,β β,βis 0.138 (0.102-0.187). In 4 ewes the mean MCR for E2β is 87 α 7 1 of blood/day/kg and the mean [ρ]1,β β,β is 0.156 (0.11_ 0.221). There is no significant difference between these MCR's and [ρ]β,β values. For both steroids there appears to be a high degree of extra-splanchnic metabolism. The conversion of each steroid to estradiol-17α has also been measured and the results suggest that the conversion of estradiol-17β to estradiol- 17α occurs to some extent through pathways not involving the blood pool of free estrone. (Endocrinology 91: 1450, 1972)