STARTLE GATING DEFICITS OCCUR ACROSS PREPULSE INTENSITIES IN SCHIZOPHRENIC-PATIENTS
STARTLE GATING DEFICITS OCCUR ACROSS PREPULSE INTENSITIES IN SCHIZOPHRENIC-PATIENTS
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DOI：
10.1016/0006-3223(92)90183-z
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发表时间：
1992-11-15
影响因子：
10.6
通讯作者：
BRAFF, D
中科院分区：
文献类型：
--
作者：
GRILLON, C;AMELI, R;BRAFF, D
对14例年龄匹配、性别匹配的精神分裂症患者和14例正常人进行了不同强度的脉冲前刺激对惊厥反射的抑制作用。受试者被呈现由脉冲前刺激或不脉冲刺激的白噪声(106dBA)组成的令人震惊的刺激。采用四种脉冲前刺激强度：75、80、85和90dBA。在整个测试过程中，背景噪音保持在70dBA。与精神分裂症患者相比，控制组的脉冲前刺激更有效地抑制了惊跳反射，精神分裂症患者表现出缺乏对惊跳反射的脉冲前抑制(门控)。这些结果表明，精神分裂症患者在相当大的背景噪声与脉搏前比率的范围内损害了中枢抑制机制。需要进一步的研究来明确哪些比率在引发脉冲前抑制(PPI)以及区分精神分裂症组和对照组方面是最佳的。
The effects of prepulse stimuli of different intensities in inhibiting the startle reflex was assessed in 14 age-matched and gender-matched schizophrenic patients and 14 normal controls. The subjects were presented with startling stimuli consisting of bursts of white noise (106 dBA) with or without prepulse stimuli. Four intensities of prepulse stimuli were utilized: 75, 80, 85, and 90 dBA. Throughout the testing, the background noise was maintained at 70 dBA. The prepulse stimuli more effectively inhibited the startle reflex in the control group compared to the schizophrenic patients who showed deficient prepulse inhibition (gating) of the startle reflex. These results suggest that schizophrenics have impaired central inhibitory mechanisms over a fairly broad range of background noise to prepulse ratios. Further studies are needed to clarify exactly which ratios are optimal in eliciting prepulse inhibition (PPI) and in differentiating between schizophrenic and control groups.