TUMORS OF PINEAL PARENCHYMAL-CELLS - A CORRELATION OF HISTOLOGICAL FEATURES, INCLUDING NUCLEOLAR ORGANIZER REGIONS, WITH SURVIVAL IN 35 CASES
TUMORS OF PINEAL PARENCHYMAL-CELLS - A CORRELATION OF HISTOLOGICAL FEATURES, INCLUDING NUCLEOLAR ORGANIZER REGIONS, WITH SURVIVAL IN 35 CASES
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DOI：
10.1016/0046-8177(95)90110-8
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发表时间：
1995-01-01
期刊：
影响因子：
3.3
通讯作者：
MCCARTHY, WF
中科院分区：
文献类型：
--
作者：
MENA, H;RUSHING, EJ;MCCARTHY, WF
我们研究了 35 例松果体实质肿瘤，包括 11 例松果体母细胞瘤、21 例松果体细胞瘤和 3 例混合松果体细胞瘤-松果体母细胞瘤。松果体母细胞瘤最常见于儿童（平均年龄 12.6 岁）。 7 名患者（其中 5 名患有远处转移且死亡）的术后中位生存期为 24 个月。这 21 个松果体细胞瘤发现于老年人（平均年龄 26.8 岁）。 4 名松果体细胞瘤患者死亡；术前两次，术后立即两次。其余 17 名患者术后存活时间为 6 至 118 个月。在婴儿中发现了两种混合性松果体细胞瘤-松果体母细胞瘤，这些患者在活检后几个月死亡，而第三名患者是一名成人，在切除和照射后 46 个月时仍然存活。松果体母细胞瘤和松果体细胞瘤均对神经丝蛋白、突触素、胶质纤维酸性蛋白、S-100 蛋白、视网膜-S 抗原和视紫红质表现出不同的免疫反应性。突触素染色的阳性细胞百分比最高。三个松果体细胞瘤表现出神经节分化，其中两个还表现出神经胶质成分。预后不能与分化程度不同相关。银染核仁组织区 (AgNOR) 计数比较松果体母细胞瘤和松果体细胞瘤表明前者比后者增殖更活跃，而混合松果体细胞瘤-松果体母细胞瘤则表现出中等活性。三个肿瘤组内 AgNOR 评分与预后之间没有相关性。嗡嗡声 26:20-30。版权所有 (C) 1995 W.B.桑德斯公司
We studied 35 parenchymal neoplasms arising in the pineal gland, including 11 pineoblastomas, 21 pineocytomas, and three mixed pineocytoma-pineoblastomas. Pineoblastomas were most commonly found in children (mean age, 12.6 years). The median postsurgical length of survival for seven patients, including five with remote metastases, with fatal outcome was 24 months. The 21 pineocytomas were found in older individuals (mean age, 26.8 years). Four patients with pineocytoma died; two before surgery and two in the immediate postoperative period. The remaining 17 patients survived for intervals between 6 and 118 months after surgery. Two mixed pineocytoma-pineoblastomas were found in infants who died a few months after biopsy, whereas a third patient, an adult, was alive at 46 months after excision and irradiation. Both pineoblastoma and pineocytoma exhibited variable immunoreactivity to neurofilament proteins, synaptophysin, glial fibrillary acidic protein, S-100 protein, retinal-S antigen, and rhodopsin; the highest percentages of positive cells stained with synaptophysin. Three pineocytomas exhibited ganglionic differentiation and two of them also showed a glial component. Prognosis could not he correlated with the degree of divergent differentiation. Comparison of silver-stained nucleolar organizer region (AgNOR) counts between pineoblastomas and pineocytomas suggests that the former are more actively proliferative than the latter, with mixed pineocytoma-pineoblastoma showing intermediate activity. There was no correlation between AgNOR score and prognosis within the three tumor groups. HUM PATHOL 26:20-30. Copyright (C) 1995 by W.B. Saunders Company