Effect of anterior and posterior corneal surface irregularity on vision after Descemet-stripping endothelial keratoplasty
Effect of anterior and posterior corneal surface irregularity on vision after Descemet-stripping endothelial keratoplasty
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DOI：
10.1016/j.jcrs.2008.11.062
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发表时间：
2009-04-01
影响因子：
2.8
通讯作者：
Tsubota, Kazuo
中科院分区：
文献类型：
--
作者：
Yamaguchi, Takefumi;Negishi, Kazuno;Tsubota, Kazuo
目得：评价角膜后弹力层剥脱内皮移植术（DSEK）前后角膜的不规则性及其对视力的影响。单位：日本东京庆应义塾大学医学院眼科。方法：在DSEK术前、术后1个月和3个月使用旋转Scheimpflug照相机采集角膜数据。将前后角膜抬高数据分解成一组Zernike多项式，在4.0 mm直径区域内达到8阶。计算总高阶均方根（HO-RMS）和3 - 8阶RMS。评估前后表面不规则性对视力的影响。结果：本临床研究包括12例大泡性角膜病变患者的13只眼。术前平均最佳矫正视力（BCVA）为1.11 logMAR +/- 0.5（SD），术后1个月为0.49 +/- 0.49 logMAR，3个月为0.27 +/- 0.32 logMAR。术后1个月（P = .040）和3个月（P = .048）前表面的HO-RMS显著低于术前。术后1个月（P = .45）和3个月（P = .054）后表面HO-RMS无显著差异。术后BCVA与HO-RMS显著相关（P
PURPOSE: To evaluate irregularity of the anterior and posterior cornea before and after Descemet-stripping endothelial keratoplasty (DSEK) and its effect on visual acuity.SETTING: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.METHODS: Corneal data were acquired using a rotating Scheimpflug camera before and 1 month and 3 months after DSEK. Anterior and posterior corneal elevation data were decomposed into a set of Zernike polynomials up to the 8th order within a 4.0 mm diameter region. Total higher-order root mean square (HO-RMS) and RMS from the 3rd to 8th order were calculated. The effects of anterior and posterior surface irregularity on visual acuity were evaluated.RESULTS: This clinical study comprised 13 consecutive eyes of 12 bullous keratopathy patients. The mean best corrected visual acuity (BCVA) was 1.11 logMAR +/- 0.5 (SD) preoperatively, 0.49 +/- 0.49 logMAR 1 month postoperatively, and 0.27 +/- 0.32 logMAR at 3 months. The HO-RMS of the anterior surface 1 month (P = .040) and 3 months (P = .048) postoperatively was significantly lower than preoperatively. There were no significant differences in posterior surface HO-RMS between preoperatively and 1 month (P = .45) and 3 months (P = .054). The postoperative BCVA was significantly correlated with HO-RMS (P