ASSESSMENT OF LUNG-CANCER RISK-FACTORS BY HISTOLOGIC CATEGORY
ASSESSMENT OF LUNG-CANCER RISK-FACTORS BY HISTOLOGIC CATEGORY
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DOI：
10.1093/jnci/73.2.383
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发表时间：
1984-01-01
影响因子：
10.3
通讯作者：
BLOT, WJ
中科院分区：
文献类型：
--
作者：
LUBIN, JH;BLOT, WJ
使用来自在西欧进行的一项以医院为基础的肺癌病例对照研究（7804例和15,207例对照）的数据，分析了肺癌组织学类型的风险模式。所有组织学类型的相对危险度（RR）随吸烟时间的增加而增加，尽管Kreyberg I细胞类型的危险度梯度大于腺癌，特别是鳞状细胞癌（SCC）。风险也随着戒烟后的几年急剧下降，尤其是SCC，而不是AC。调整使用持续时间后，RR与吸烟/天的数量，频率和深度的吸入和香烟消耗的分数并不一致不同的细胞类型，这表明香烟暴露的强度相关的措施对细胞类型的影响小于持续时间相关的因素。在从不吸烟的人中，不同性别的细胞类型存在显着差异，女性AC与SCC的比例（45%比25%）高于男性（35%比33%）。回顾有限的工作历史表明，职业协会也更密切相关的Kreyberg I比Kreyberg II肿瘤。
The patterns of risk by histologic type of lung cancer were analyzed with the use of data from a large hospital-based case-control study (7804 cases and 15,207 controls) of lung cancer performed in Western Europe. Relative risks (RR) increased with duration of cigarette use for all histologic types, although the gradients of risk were greater for Kreyberg I cell types, particularly squamous cell cacrcinoma (SCC), than for adenocarcinoma (AC). Risks also declined more sharply with years since cessation of smoking for all Kreyberg I cell types, in particular for SCC, rather than for AC. After adjustment for duration of use, the RR associated with number of cigarettes smoked/day, frequency and depth of inhalation and fraction of cigarette consumed were not consistently different by cell type, suggesting that intensity-related measures of cigarette exposure have less effect on cell type than duration-related factors. Among those who never smoked there were marked cell type differences by sex, with a greater proportion of AC compared to SCC for females (45 vs. 25%) than for males (35 vs. 33%). Review of limited work histories indicated that occupational associations also were more strongly related to Kreyberg I than to Kreyberg II tumors.