Tumor characterization in small animals using magnetic resonance-guided dynamic contrast enhanced diffuse optical tomography.
Tumor characterization in small animals using magnetic resonance-guided dynamic contrast enhanced diffuse optical tomography.
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DOI：
10.1117/1.3643342
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发表时间：
2011-10
影响因子：
3.5
通讯作者：
Yuting Lin;D. Thayer;O. Nalcioglu;G. Gulsen
中科院分区：
文献类型：
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作者：
Yuting Lin;D. Thayer;O. Nalcioglu;G. Gulsen
我们提出了一种磁共振 (MR) 引导的近红外动态对比增强漫反射光学断层扫描 (DCE-DOT) 系统，用于在大鼠模型中使用光学造影剂 (ICG) 和 MR 造影剂 [Gd-二乙烯三胺五乙酸 (DTPA)] 来表征肿瘤。使用组合 MRI-DOT 系统同时注射和监测 ICG 和 Gd-DTPA，从而实现两种成像模式之间的准确共同配准。使用该混合系统对携带 R3230 乳腺肿瘤的 Fisher 大鼠进行成像。首次使用 MR 解剖先验信息从 DCE-DOT 数据中恢复外源对比 ICG 的增强动力学。随着肿瘤的生长，它们会发生坏死，组织从存活状态转变为坏死状态。结果表明，当利用 MR 解剖信息时，可以根据 ICG 增强动力学更准确地区分活组织和坏死组织之间的生理变化。
We present a magnetic resonance (MR)-guided near-infrared dynamic contrast enhanced diffuse optical tomography (DCE-DOT) system for characterization of tumors using an optical contrast agent (ICG) and a MR contrast agent [Gd-diethylenetriaminepentaacetic acid (DTPA)] in a rat model. Both ICG and Gd-DTPA are injected and monitored simultaneously using a combined MRI-DOT system, resulting in accurate co-registration between two imaging modalities. Fisher rats bearing R3230 breast tumor are imaged using this hybrid system. For the first time, enhancement kinetics of the exogenous contrast ICG is recovered from the DCE-DOT data using MR anatomical a priori information. As tumors grow, they undergo necrosis and the tissue transforms from viable to necrotic. The results show that the physiological changes between viable and necrotic tissue can be differentiated more accurately based on the ICG enhancement kinetics when MR anatomical information is utilized.