Thermal Instability of Choline Chloride-Based Deep Eutectic Solvents and Its Influence on Their Toxicity-Important Limitations of DESs as Sustainable Materials
Thermal Instability of Choline Chloride-Based Deep Eutectic Solvents and Its Influence on Their Toxicity-Important Limitations of DESs as Sustainable Materials
复制标题
基于氯化胆碱的深共晶溶剂的热不稳定性及其对毒性的影响--作为可持续材料的 DES 的重要局限性
DOI：
10.1021/acs.iecr.2c01898
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发表时间：
2022-07-25
影响因子：
4.2
通讯作者：
Boczkaj, Grzegorz
中科院分区：
文献类型：
--
作者：
Marchel, Mateusz;Cieslinski, Hubert;Boczkaj, Grzegorz
低共熔溶剂（DESs）因其优异的性质而成为许多学科的研究热点。它们已经在各种各样的应用中被研究。具体而言，基于氯化胆碱（ChCl）的DES是这些流体中最常用的代表之一。然而，为了在某些领域应用DES，必须保证其稳定性、可重复使用性和生物相容性。在此背景下，研究了使用葡萄糖、丙二酸和脲作为氢键供体形成的三种基于ChCl的DES的长期稳定性。此外，首次评估了长期加热过程中可能形成的有毒副产物，并使用三种细菌菌株（大肠杆菌、铜绿假单胞菌和金黄色葡萄球菌）进行了毒理学研究。ChCl：尿素DES显示出高的长期热稳定性，并且还发现对细菌的毒性较小，因此可以被认为是绿色溶剂。ChCl：葡萄糖DES在100 ℃下由于可能的焦糖化而开始分解，并且在更高的温度下进一步促进分解。DES降解后对细菌的毒性影响不大，抗菌性能较低。不建议使用ChCI：丙二酸DES，因为该DES因丙二酸酯化和分解为乙酸和二氧化碳而显示出热不稳定性。此外，与本研究中测定的其他DES相比，报告了该DES的高毒性。
Deep eutectic solvents (DESs) have become a hot topic in many branches of science due to their remarkable properties. They have been studied in a wide variety of applications. In particular, choline chloride (ChCl)-based DESs are one of the most commonly used representatives of these fluids. Nevertheless, in order to apply DESs in some fields, it is essential to guarantee their stability, reusability, and biocompatibility. In this context, the long-term stability of three ChCI-based DESs formed using glucose, malonic acid, and urea as hydrogen bond donors was investigated. Furthermore, the possible formation of toxic by-products during long-term heating was evaluated for the first time, and toxicological studies using three bacterial strains (Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus) were performed. ChCl:urea DES revealed a high long-term thermal stability and was also found to be less toxic to the bacteria and thus can be considered as green solvent. ChCl:glucose DES started to decompose as a result of possible caramelization at 100 degrees C, and decomposition was further promoted at more elevated temperatures. Degradation of this DES did not affect greatly the toxicity toward bacteria, and low antibacterial properties were observed. The applicability of ChCI:malonic DES is not recommended as this DES was shown to be thermally unstable due to esterification and decomposition of malonic acid into acetic acid and carbon dioxide. Moreover, high toxicity of this DES in comparison to other DESs assayed in this study was reported.