Diffusion tensor imaging and fibre tracking in cervical spondylotic myelopathy
Diffusion tensor imaging and fibre tracking in cervical spondylotic myelopathy
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DOI：
10.1007/s00330-010-1927-z
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发表时间：
2011-02-01
影响因子：
5.9
通讯作者：
Cotten, Anne
中科院分区：
文献类型：
--
作者：
Budzik, Jean-Francois;Balbi, Vincent;Cotten, Anne
目的(1)应用纤维束成像技术获得脊髓型颈椎病(CSM)患者颈髓的显微结构参数(分数各向异性：FA，平均弥散率：MD)；(2)将DTI参数与临床(3)及常规序列提供的信息进行比较。方法对20例有症状的脊髓型颈椎病患者进行DTI检查，并与15例志愿者对照。根据患者C2-C3节段和压缩节段以及对照组C2-C3和C4-C7节段的气管造影术图像计算FA和MD。结果患者在压缩水平的FA值明显低于志愿者在C4~C7水平的FA值。压缩节段FA与临床评分呈显著正相关。T2加权像信号增强与FA值、MD值及临床评分均无相关性。结论FA值与部分患者的临床评分显著相关。T2上脊髓高信号与DTI参数及临床评估均无相关性，提示FA比T2更敏感。
Objectives To (1) obtain microstructural parameters (Fractional Anisotropy: FA, Mean Diffusivity: MD) of the cervical spinal cord in patients suffering from cervical spondylotic myelopathy (CSM) using tractography, (2) to compare DTI parameters with the clinical assessment of these patients (3) and with information issued from conventional sequences.Methods DTI was performed on 20 symptomatic patients with cervical spondylotic myelopathy, matched with 15 volunteers. FA and MD were calculated from tractography images at the C2-C3 level and compressed level in patients and at the C2-C3 and C4-C7 in controls. Patients were clinically evaluated using a self-administered questionnaire.Results The FA values of patients were significantly lower at the compressed level than the FA of volunteers at the C4-C7 level. A significant positive correlation between FA at the compressed level and clinical assessment was demonstrated. Increased signal intensity on T2-weighted images did not correlate either with FA or MD values, or with any of the clinical scores.Conclusion FA values were significantly correlated with some of the patients' clinical scores. High signal intensity of the spinal cord on T2 was not correlated either with the DTI parameters or with the clinical assessment, suggesting that FA is more sensitive than T2 imaging.