Glucose transporter (GLUT1) expression by canine brain microvessel endothelial cells in culture: an immunocytochemical study.

Glucose transporter (GLUT1) expression by canine brain microvessel endothelial cells in culture: an immunocytochemical study.
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培养物中犬脑微血管内皮细胞的葡萄糖转运蛋白(GLUT1)表达:一项免疫细胞化学研究。

DOI:
10.1007/978-1-4615-2920-0_3
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发表时间:
1993
影响因子:
--
通讯作者:
Drewes,LR
Drewes,LR
中科院分区:
医学4区
文献类型:
--
作者:
Hemmila,JM;Drewes,LR

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脑微血管内皮细胞(BMEC)形成一个选择性渗透屏障,称为血脑屏障(BBB)(16)。通过在相邻BMEC质膜之间形成紧密连接,在结构上维持屏障(1)。因此,在血液和脑之间交换的代谢物必须通过BMEC,并且BMEC由与非屏障来源的内皮细胞相比高度表达的转运系统标记。
Brain microvessel endothelial cells (BMEC) form a selectively permeable barrier known as the blood-brain barrier (BBB) (16). The barrier is maintained structurally by the formation of tight junctions between adjacent BMEC plasma membranes (1). As a result, metabolites exchanged between the blood and brain must pass through the BMEC and BMEC, are marked by transport systems that are highly expressed in comparison to endothelial cells of non-barrier origin.