Yoga Prevents Gray Matter Atrophy in Women at Risk for Alzheimer's Disease: A Randomized Controlled Trial.
Yoga Prevents Gray Matter Atrophy in Women at Risk for Alzheimer's Disease: A Randomized Controlled Trial.
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DOI：
10.3233/jad-215563
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发表时间：
2022
影响因子：
4
通讯作者：
Lavretsky, Helen
中科院分区：
文献类型：
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作者：
Krause-Sorio, Beatrix;Siddarth, Prabha;Kilpatrick, Lisa;Milillo, Michaela M.;Aguilar-Faustino, Yesenia;Ercoli, Linda;Narr, Katherine L.;Khalsa, Dharma S.;Lavretsky, Helen
关键词：
女性、主观认知衰退（SCD）和心血管危险因素（CVRFs）是阿尔茨海默病（AD）发病的已知危险因素。我们先前已证明，瑜伽可改善轻度认知障碍老年人的抑郁状况、心理韧性、记忆力和执行功能，提高海马体胆碱浓度，并调节大脑的连接性。
在这项研究（NCT03503669）中，我们对比记忆增强训练（MET），研究了患有SCD和CVRFs的老年女性在进行三个月瑜伽练习后大脑灰质体积（GMV）的变化。
11名患有CVRF和SCD的女性（平均年龄 = 61.45岁，标准差 = 6.58）完成了为期12周的昆达里尼瑜伽和科尔坦唱诵（KY + KK）训练，同时有11名女性（平均年龄 = 64.55岁，标准差 = 6.41）接受了MET训练。在基线和12周时对焦虑、心理韧性、压力和抑郁进行评估，同时进行T1加权磁共振成像扫描（西门子3T Prisma扫描仪）。我们使用Freesurfer 6.0软件，并通过蒙特卡洛模拟（α = 0.05）来检验GMV变化的组间差异。对海马体和杏仁核进行了感兴趣区域分析。
与KY + KK相比，MET显示左侧前额叶、中央前回和后回、缘上回、颞上回和距状沟周围皮质、右侧中央旁小叶、中央后回、顶叶上下回、颞上沟岸以及岛盖部的GMV减少。瑜伽练习后右侧海马体体积增加，但未通过校正。
与MET相比，瑜伽训练在预防神经退行性变化和认知衰退方面可能具有神经保护作用，即使是在较短的时间间隔内。未来的分析将探讨两组在功能连接性方面的变化。
Female sex, subjective cognitive decline (SCD), and cardiovascular risk factors (CVRFs) are known risk factors for developing Alzheimer’s disease (AD). We previously demonstrated that yoga improved depression, resilience, memory and executive functions, increased hippocampal choline concentrations, and modulated brain connectivity in older adults with mild cognitive impairment. In this study (NCT03503669), we investigated brain gray matter volume (GMV) changes in older women with SCD and CVRFs following three months of yoga compared to memory enhancement training (MET). Eleven women (mean age = 61.45, SD = 6.58) with CVRF and SCD completed twelve weeks of Kundalini Yoga and Kirtan Kriya (KY + KK) while eleven women (mean age = 64.55, SD = 6.41) underwent MET. Anxiety, resilience, stress, and depression were assessed at baseline and 12 weeks, as were T1-weighted MRI scans (Siemens 3T Prisma scanner). We used Freesurfer 6.0 and tested group differences in GMV change, applying Monte-Carlo simulations with alpha = 0.05. Region-of-interest analysis was performed for hippocampus and amygdala. Compared to KY + KK, MET showed reductions in GMV in left prefrontal, pre- and post-central, supramarginal, superior temporal and pericalcarine cortices, right paracentral, postcentral, superior and inferior parietal cortices, the banks of the superior temporal sulcus, and the pars opercularis. Right hippocampal volume increased after yoga but did not survive corrections. Yoga training may offer neuroprotective effects compared to MET in preventing neurodegenerative changes and cognitive decline, even over short time intervals. Future analyses will address changes in functional connectivity in both groups.