Adiponectin can be a good predictor of urodynamic detrusor underactivity: a prospective study in men with lower urinary tract symptoms
Adiponectin can be a good predictor of urodynamic detrusor underactivity: a prospective study in men with lower urinary tract symptoms
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DOI：
10.1007/s00345-023-04341-y
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发表时间：
2023-02
影响因子：
3.4
通讯作者：
Tomohiro Ishikawa;Y. Matsukawa;Y. Naito;S. Ishida;T. Majima;M. Gotoh
中科院分区：
文献类型：
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作者：
Tomohiro Ishikawa;Y. Matsukawa;Y. Naito;S. Ishida;T. Majima;M. Gotoh
目的探讨循环脂联素能否预测下尿路症状患者的膀胱功能，特别是逼尿肌活动不足(DU)。方法根据是否存在DU，将13 0例未接受治疗的非神经源性LUTS患者分为两组(DU组和非DU组)，其中DU定义为膀胱收缩指数 <； 10 0，膀胱出口梗阻指数(BOOI) <； 40。通过单因素、二项Logistic回归和受试者操作特征(ROC)曲线分析，评价血清脂联素水平对包括DU在内的尿动力学功能的影响。结果总共分析了118名男性的数据，其中39名(33.0%)有DU(DU组)，79名(67.0%)没有DU(非DU组)。DU组血清脂联素中位数显著低于非DU组(6.2vs12.6ug/mL，p<； 0.001)。在二项Logistic回归分析中，低脂联素、较小的膀胱内前列腺突出和较低的膀胱排尿效率是DU的显著相关因素。在ROC分析中，血清脂联素对DU诊断的曲线下面积最高(0.849)。血清脂联素水平作为诊断DU的临界值，其敏感度和特异度分别为79%和90%。结论血清脂联素水平与男性LUTS患者的膀胱功能密切相关，可作为预测DU的有用指标。
PurposeTo investigate whether circulating adiponectin, which is considered a possible marker of anti-atherogenic effects, is a useful predictor of bladder function, especially detrusor underactivity (DU), in men with lower urinary tract symptoms (LUTS).MethodsA total of 130 treatment-naïve men with non-neurogenic LUTS were prospectively stratified into two groups (the DU and non-DU groups) based on the presence or absence of DU, where DU is defined as a bladder contractility index < 100 and bladder outlet obstruction index (BOOI) < 40. The impact of serum adiponectin levels on urodynamic function, including DU, was assessed using univariate, binomial logistic regression, and receiver operating characteristic (ROC) curve analyses.ResultsIn total, data from 118 men were analyzed; 39 (33.0%) had DU (DU group) and 79 (67.0%) did not have DU (non-DU group). The median serum adiponectin in the DU group was significantly lower than in the non-DU group (6.2 vs 12.6 µg/mL,p< 0.001). In the binomial logistic regression analysis, lower adiponectin, smaller intravesical prostatic protrusion, and lower bladder voiding efficiency were significant factors related to DU. In the ROC analyses, serum adiponectin had the highest area under the curve value for DU diagnosis (0.849). Additionally, a cutoff value of 7.9 µg/mL for serum adiponectin level was identified for DU, which yielded a sensitivity and specificity of 79% and 90%, respectively.ConclusionsThe serum adiponectin level was significantly associated with bladder function and may be a useful marker for predicting DU in men with LUTS.