Threshold for the pleasurable effects of nicotine are lower than its reinforcing effects during self-administration.
Threshold for the pleasurable effects of nicotine are lower than its reinforcing effects during self-administration.
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尼古丁的愉悦效果阈值低于其自我给药期间的增强效果。
DOI：
10.1037/pha0000556
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发表时间：
2023
影响因子：
2.3
通讯作者：
Sofuoglu,Mehmet
中科院分区：
文献类型：
--
作者：
MacLean,RRoss;Eid,Tore;Parida,Suprit;Gueorguieva,Ralitza;DeVito,EliseE;Sofuoglu,Mehmet
最近的一项研究表明，在单个采样期内，发现0.1 mg静脉（IV）尼古丁（与安慰剂相比）是主观和生理药物效应的阈值。本研究是一项次要分析，评价当受试者有重复机会选择尼古丁与安慰剂的盲态剂量时，主观和生理效应的阈值是否相似。我们还研究了吸烟渴望、戒断和尼古丁代谢率是否会影响尼古丁强化，尼古丁强化的定义是尼古丁选择的数量比安慰剂多。年轻成人（n= 34; 68%男性），每日吸烟者在整夜戒烟后进行了5次实验室检查。在对IV剂量的尼古丁（0.0125、0.025、0.05、0.1或0.2 mg/70 kg）与生理盐水（安慰剂）进行采样后，参与者完成了尼古丁自我给药（NSA）程序，其中包括10次自我给药IV剂量尼古丁或安慰剂的机会。NSA期间尼古丁的主观积极作用阈值等于或低于采样期，0.05-0.1 mg vs 0.1 mg。NSA期间尼古丁诱导的心率增加阈值高于采样期间（0.2 mg vs. 0.1 mg）。较高的基线渴望和尼古丁代谢物比率（NMR）分别与0.2 mg和0.1 mg剂量的尼古丁强化相关（p<0.05）。05）。结果表明，NSA期间的主观影响报告的剂量低于采样期。总的来说，烟草产品被认为是强化的亚阈值，应仔细评估其主观影响，包括其歧视性刺激效应。（PsycInfo数据库记录（c）2023阿帕，保留所有权利）
A recent study demonstrated that during a single sampling period, 0.1 mg of intravenous (IV) nicotine (vs. placebo) was found to be the threshold for subjective and physiological drug effects. The present study is a secondary analysis evaluating whether the threshold for subjective and physiological effects is similar when the subject has repeated opportunities to choose blinded doses of nicotine versus placebo. We also examined whether cigarette craving, withdrawal, and rate of nicotine metabolism affected nicotine reinforcement, defined by a greater number of nicotine choices than placebo. Young adult (n= 34; 68% male), daily smokers had five laboratory sessions after overnight abstinence. After sampling an IV dose of nicotine (0.0125, 0.025, 0.05, 0.1, or 0.2 mg/70 kg) versus saline (placebo), participants completed a nicotine self-administration (NSA) procedure that included 10 opportunities to self-administer IV dose of nicotine or placebo. The threshold for subjective positive effects of nicotine during the NSA was equal to or lower than the sampling period, 0.05–0.1 mg versus 0.1 mg. The threshold for nicotine-induced heart rate increase was higher during the NSA than during the sampling period (0.2 mg vs. 0.1 mg). Higher baseline craving and nicotine metabolite ratio (NMR) were associated with nicotine reinforcement at 0.2 mg and 0.1 mg doses, respectively (p<. 05). The results suggest that subjective effects during NSA are reported at doses lower than the sampling period. Taken together, tobacco products thought to be subthreshold for reinforcement should be carefully evaluated for their subjective effects, including their discriminative stimulus effects.(PsycInfo Database Record (c) 2023 APA, all rights reserved)