Retroviral RNA packaging: sequence requirements and implications.
Retroviral RNA packaging: sequence requirements and implications.
复制标题
逆转录病毒 RNA 包装：序列要求和影响。
DOI：
10.1007/978-3-642-75218-6_5
复制
发表时间：
1990
影响因子：
--
通讯作者：
A. Miller
中科院分区：
文献类型：
--
作者：
M. Linial;A. Miller
Unlike many animal viruses, infection by retroviruses generally does not lead to cessation of host RNA synthesis. Despite the high levels of host RNA in infected cells, the vast majority of retroviral particles contain a precise genomic complex consisting of two molecules of genomic RNA, rather than cellular or subgenomic viral mRNAs. Thus, the retroviral genome must be selected for encapsidation against a high background of cellular RNAs. It is therefore surprising that the retroviral genome is structurally similar to that of cellular mRNA. For instance, both molecules contain a 5′ m7 G cap and several hundred A residues at the 3′ terminus (reviewed in Coffin 1984a, 1985). Viral subgenomic mRNAs are even more similar to genomic RNA. The ability of the retroviral particle to choose correctly genomic RNA from the vast excess of heterologous molecules implies that specific sequences are present within the genome which direct the efficient encapsidation of the correct RNAs. Analysis of spontaneous and engineered mutants of both avian and murine retroviruses has in fact revealed that cis-acting sequences are involved and are present in the retroviral genome.
登录
查看更多内容
禽逆转录病毒核衣壳蛋白 pp12 的位点特异性磷酸化调节与病毒 RNA 的结合。
DOI：
--
发表时间：
1985
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Fu,X;Phillips,N;Jentoft,J;Tuazon,PT;Traugh,JA;Leis,J
通讯作者：
Leis,J
禽逆转录病毒核衣壳蛋白的定点诱变，第 12 页，丝氨酸 40，体内磷酸化的主要位点。
DOI：
--
发表时间：
1988
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Fu,XD;Tuazon,PT;Traugh,JA;Leis,J
通讯作者：
Leis,J
DOI：
10.1073/pnas.85.22.8420
发表时间：
1988-11-01
影响因子：
11.1
作者：
GORELICK, RJ;HENDERSON, LE;REIN, A
通讯作者：
REIN, A
禽逆转录病毒核衣壳蛋白的定点诱变，第 12 页。影响体外 RNA 结合的突变会阻止病毒复制。
DOI：
--
发表时间：
1988
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Fu,XD;Katz,RA;Skalka,AM;Leis,J
通讯作者：
Leis,J
影响因子：
10.7
作者：
H. Temin
通讯作者：
H. Temin