Antineoplastic agents. 76. The sea urchin Strongylocentrotus droebachiensis.
Antineoplastic agents. 76. The sea urchin Strongylocentrotus droebachiensis.
复制标题
抗肿瘤剂。
DOI：
10.1021/np50018a015
复制
发表时间：
1981
影响因子：
5.1
通讯作者：
Herald,CL
中科院分区：
文献类型：
--
作者：
Pettit,GR;Hasler,JA;Paull,KD;Herald,CL
一种基于37，000 g离心的改进方法已被开发用于从Droebachiensis（Müller）中分离出β-糖蛋白圆线虫抑制素1（Strongylo-centrotus roebachiensis（Müller））。还发现绿色海胆含有第二种蛋白质抗癌成分，称为圆线虫抑制素2。用圆线虫抑制素2治疗小鼠P3 S8淋巴细胞性白血病，在4.5 mg/kg剂量下导致39-42%的寿命延长。在海洋棘皮动物门中，棘虫亚门包含没有臂的自由生活的棘皮动物，例如近800种海胆（海胆纲）。通常这些动物的管足和可移动的脊柱用于运动。腹侧包含有五颗牙齿的嘴（亚里士多德的灯笼），肛门在上侧。海胆生活在海底，以植物和动物为食。广泛分布（环极）的绿色海胆Strongylocentrotus droebachiensis Müller（海胆目，球海胆科）具有腺型（2）pedicellariae毒腺，通过固定猎物（3）来帮助进食和防御。[2]例如，用硫酸锌溶液处理，会引起类似于海胆被捕食性海星Marthalus as glacialis攻击时所见的逃避反应;球状的棘足虫张开下颚抬起（4）。
An improved procedure based on centrifugation at 37,000 g has been developed for isolating the antineoplastic glycoprotein strongylostatin 1 from Strongylo-centrotus droebachiensis (Müller). The green sea urchin has also been found to contain a second protein anticancer constituent designated strongylostatin 2. Treatment of the murine P3S8 lymphocytic leukemia with strongylostatin 2 resulted in 39-42% life extension at a dose of 4.5 mg/'kg.In the marine phylum Echinodermata the subphylum Echinozoa contains the free-living echinoderms without arms such as the nearly eight hundred sea urchins (Echinoidea class). Generally the tube feet and movable spines of these animals are used for locomotion. The ventral side contains the mouth ringed with five teeth (Aristotle's lantern) and the anus is on the upper side. The sea urchins are bottom-living and feed on both plants and animals. The broad ranging (circumpolar) green urchin Strongylocentrotus droebachiensis Müller (Echinocea superorder, Strongylocentrotidae family) bears glandular-type (2) pedicellariae venom glands which assist in feeding and defense by immobilizing prey (3). 2 For example, treatment with a solution of zinc sulfate evokes an escape response similar to that seen when the urchin is attacked by the predatory starfish Marthasterias glacialis; the globiferous pedicellariae are raised with open jaws (4).