Direct catalytic enantio- and diastereoselective ketone aldol reactions of isocyanoacetates.
Direct catalytic enantio- and diastereoselective ketone aldol reactions of isocyanoacetates.
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DOI：
10.1002/anie.201411852
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发表时间：
2015-04-13
期刊：
影响因子：
--
通讯作者：
Dixon DJ
中科院分区：
文献类型：
--
作者：
de la Campa R;Ortín I;Dixon DJ
研究了未活化酮与异氰乙酸酯亲核试剂的催化不对称羟醛加成/环化反应。奎宁衍生的氨基膦预催化剂和银氧化物是一个有效的二元催化体系，促进了反应的进行，得到了具有完全取代的立体中心的手性恶唑啉，具有良好的非对映选择性和优异的对映选择性。
A catalytic asymmetric aldol addition/cyclization reaction of unactivated ketones with isocyanoacetate pronucleophiles has been developed. A quinine-derived aminophosphine precatalyst and silver oxide were found to be an effective binary catalyst system and promoted the reaction to afford chiral oxazolines possessing a fully substituted stereocenter with good diastereoselectivities and excellent enantioselectivities.