Neural control of renal excretory function during behavioral stress in conscious dogs.
Neural control of renal excretory function during behavioral stress in conscious dogs.
复制标题
清醒狗行为应激期间肾脏排泄功能的神经控制。
DOI：
10.1152/ajpregu.1983.245.2.r251
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Obrist,PA
中科院分区：
文献类型：
--
作者：
Koepke,JP;Light,KC;Obrist,PA
在30只清醒的狗中研究了行为应激（厌恶性条件反射）排泄反应的肾脏和神经机制。21只狗在应激期间尿流减少超过20%，而9只狗减少不到10%。在21只肾反应性犬中的11只中，尿流量（42%）和钠排泄（45%）减少与肾小球滤过率（-1.5%; GFR;菊粉清除率）和有效肾血流量（-4%; RBF;对氨基马尿酸清除率）不变相关。在其他10只肾反应性犬中，尿流量（54%）和钠排泄（52%）出现类似下降，GFR（24%）和RBF（27%）下降。在所有30只狗中，压力期间心血管活动的增加与肾脏排泄的减少有关。手术肾神经切除取消了4的5只狗的排泄反应的压力。这些结果表明，大多数犬的排泄反应1）主要通过肾小管重吸收增加而非GFR降低介导，2）通过与心血管反应的中枢整合介导，3）通过肾神经介导。
The renal and neural mechanisms underlying the excretory response to behavioral stress (aversive conditioning) were examined in 30 conscious dogs. Twenty-one dogs decreased urine flow more than 20% during stress, whereas 9 dogs showed less than a 10% decrease. In 11 of the 21 renal-reactive dogs, decreases in urine flow (42%) and sodium excretion (45%) were associated with unchanged glomerular filtration (-1.5%; GFR; inulin clearance) and effective renal blood flow (-4%; RBF; p-aminohippurate clearance). In the other 10 renal-reactive dogs, similar declines in urine flow (54%) and sodium excretion (52%) occurred with decreases in GFR (24%) and RBF (27%). Among all 30 dogs, greater increases in cardiovascular activity during stress were associated with greater decreases in renal excretion. Surgical renal denervation abolished the excretory response to stress in 4 of 5 dogs. These findings suggest that excretory responses in most dogs are mediated 1) primarily via increased tubular reabsorption rather than decreased GFR, 2) via central integration with cardiovascular responses, and 3) via the renal nerves.