Severity of depression and risk for subsequent dementia: cohort studies in China and the UK
Severity of depression and risk for subsequent dementia: cohort studies in China and the UK
复制标题
DOI：
10.1192/bjp.bp.107.044974
复制
发表时间：
2008-11-01
影响因子：
10.5
通讯作者：
Copeland, John R.
中科院分区：
文献类型：
--
作者：
Chen, Ruoling;Hu, Zhi;Copeland, John R.
研究背景抑郁症和痴呆症常同时存在。抑郁综合征和抑郁症严重程度与痴呆事件的关系研究甚少。AimsTo determine the effects of depression syndromes and cases of depression on the risk of incident dementia. MethodChinese and the participants in the UK aged >= 65 years without dementia were interviewed using the Geriatric Mental State interview and reinterviewed I year later in 1254 Chinese，和2年和4年后，分别在3341和2157英国参与者（老龄化在利物浦项目健康方面：医学研究理事会的一部分-认知功能和老龄化研究）。患痴呆症的风险增加，不是在抑郁症不太严重的情况下，而是在最严重的情况下。1年随访时，中国受试者的多重校正风险比（HR）=5.44（95% CI 1.67-17.8），2年和4年随访时，英国受试者的HR分别为2.47（95% CI 1.25-4.89）和1（95% CI 1.18-5.80）。在年轻的participant.ConclusionsOnly最严重的综合征和抑郁症的情况下是痴呆症的危险因素。资金详情见鸣谢。
BackgroundDepression and dementia often exist concurrently. The associations of depressive syndromes and severity of depression with incident dementia have been little studied.AimsTo determine the effects of depressive syndromes and cases of depression on the risk of incident dementia.MethodParticipants in China and the UK aged >= 65 years without dementia were interviewed using the Geriatric Mental State interview and re-interviewed I year later in 1254 Chinese, and 2 and 4 years later in 3341 and 2157 British participants respectively (Ageing in Liverpool Project Health Aspects: part of the Medical Research Council - Cognitive Function and Ageing study).ResultsIncident dementia was associated with only the most severe depressive syndromes in both Chinese and British participants. The risk of dementia increased, not in the less severe cases of depression but in the most severe cases. The multiple adjusted hazard ratio (HR)=5.44 (95% CI 1.67-17.8) for Chinese participants at 1-year follow-up, and HR=2.47 (95% CI 1.25-4.89) and 1 (95% Cl 1.18-5.80) for British participants at 2- and 4-year follow-up respectively. The effect was greater in younger participants.ConclusionsOnly the most severe syndromes and cases of depression are a risk factor for dementia.Declaration of interestNone. Funding detailed in Acknowledgements.