SB-203207 and SB-203208, two novel isoleucyl tRNA synthetase inhibitors from a Streptomyces sp II.: Structure determination
SB-203207 and SB-203208, two novel isoleucyl tRNA synthetase inhibitors from a Streptomyces sp II.: Structure determination
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DOI：
10.7164/antibiotics.53.364
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发表时间：
2000-04-01
影响因子：
3.3
通讯作者：
Tyler, JW
中科院分区：
文献类型：
--
作者：
Houge-Frydrych, CSV;Gilpin, ML;Tyler, JW
SE-203207和SE-203208是从链霉菌中分离到的两种新的异亮氨酰tRNA合成酶抑制剂，它们的结构与altemicidin相似。SE-203207和SE-203208的结构已通过光谱技术、衍生化、水解研究的组合进行推断，发现为4-氨基羰基-7-{[（2-氨基-3-甲基戊酰基）氨基磺酰基]乙酰胺基}-2，4a，5，6，7，7a-六氢-6-羟基-2-甲基-1H-2-吡啶-7-羧酸（1）和4-氨基羰基-7-{[（2-氨基-3-甲基戊酰基）-氨基磺酰基]乙酰氨基}-2，4a，5，6，7，7a-六氢-6-（2-氨基-3-苯基丁酰氧基）-2-甲基-1H-2-吡啶-7-羧酸（2）。
Two novel isoleucyl tRNA synthetase inhibitors, SE-203207 and SE-203208 have been isolated from a Streptomyces sp. and found to be structurally related to altemicidin. Structures of SE-203207 and SE-203208 have been deduced by a combination of spectroscopic techniques, derivatisation, hydrolysis studies and found to be 4-(aminocarbonyl)-7-{[(2-amino-3 -methylpentanoyl)aminosulphonyl]acetamido}-2,4a,5,6,7,7a-hexahydro-6-hydroxy-2-methyl-1H-2-pyrindine-7-carboxylic acid (1) and 4-(aminocarbonyl)-7-{[(2-amino-3-methyl pentanoyl)-aminosulphonyl]acetamido}-2,4a,5,6,7,7a-hexahydro-6-(2-amino-3-phenylbutanoyl oxy)-2-methyl-1H-2-pyrindine-7-carboxylic acid (2), respectively.