Toxicologic studies on o-chlorobenzylidene malononitrile.
Toxicologic studies on o-chlorobenzylidene malononitrile.
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DOI：
10.1016/0041-008x(62)90093-5
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发表时间：
1962-09
影响因子：
3.8
通讯作者：
C. L. Punte;J. T. Weimer;T. A. Ballard;J. L. Wilding
中科院分区：
文献类型：
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作者：
C. L. Punte;J. T. Weimer;T. A. Ballard;J. L. Wilding
邻氯苄叉丙二腈对家兔的急性静脉LD_（50）约为8 mg/kg。小鼠皮下注射LD_（50）> 800 mg/kg。邻氯亚苄基丙二腈放置在家兔眼中时仅引起结膜炎。邻氯亚苄基丙二腈对大鼠、小鼠、豚鼠和鸽子的急性吸入LCt 50分别为32，500、43，500、8300、17，300和36，000 mg min/m3。青霉素和异丙肾上腺素的管理没有改变豚鼠吸入邻氯苄叉丙二腈后的死亡率反应。每日暴露于邻氯亚苄基丙二腈，每周5天，持续5周，对犬无明显影响。每日接触（3 600毫克/分/立方米）导致一些接触大鼠死亡。邻氯苯亚甲基丙二腈是一种强效的催泪剂和催泪剂，在动物中的致死和刺激性空气浓度之间的比率很高。
The acute intravenous LD50of o-chlorobenzylidene malononitrile for rabbits is about 8 mg/kg. The subcutaneous LD50for mice is greater than 800 mg/kg. o-Chlorobenzylidene malononitrile caused only conjunctivitis when placed in the eyes of rabbits. The acute inhalation LCt50of o-chlorobenzylidene malononitrile for rats, mice, guinea pigs, and pigeons is 32,500, 43,500, 8300, 17,300 and 36,000 mg min/m3respectively. The administration of penicillin and isoproterenol did not alter mortality responses in guinea pigs following inhalation of o-chlorobenzylidene malononitrile. Daily exposure to o-chlorobenzylidene malononitrile, 5 days a week for 5 weeks, had no apparent effect on dogs. Daily exposure (3600 mg min/m3) caused death of some of the exposed rats. o-Chlorobenzylidene malononitrile is a potent sternutator and lacrimator and has a high ratio between the lethal and irritating airborne concentration in animals.