Pd/P(t-Bu)3:: A mild and general catalyst for stille reactions of aryl chlorides and aryl bromides
Pd/P(t-Bu)3:: A mild and general catalyst for stille reactions of aryl chlorides and aryl bromides
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DOI：
10.1021/ja020012f
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发表时间：
2002-06-05
影响因子：
15
通讯作者：
Fu, GC
中科院分区：
文献类型：
--
作者：
Littke, AF;Schwarz, L;Fu, GC
Pd/P(t-Bu)(3)是芳基氯化物和溴化物的Stille反应的一种异常活跃的催化剂，为一些长期存在的挑战提供了解决方案。一系列史无前例的芳基氯化物可以与一系列有机锡试剂交叉偶联，包括SnBU4。可以合成非常受阻的联芳基(例如，四邻位取代的联芳基)，并且可以在三氟芳基化合物的存在下偶联芳基氯化物。该方法是用户友好的，因为商业上可获得的络合物Pd(P(t-Bu)(3))(2)是有效的。Pd/P(t-Bu)(3)也是芳基溴化物Stille反应的活性催化剂，提供了第一个室温交叉偶联的通用方法。
Pd/P(t-Bu)(3) serves as an unusually reactive catalyst for Stille reactions of aryl chlorides and bromides, providing solutions to a number of long-standing challenges. An unprecedented array of aryl chlorides can be cross-coupled with a range of organotin reagents, including SnBU4. Very hindered biaryls (e.g., tetra-ortho-substituted) can be synthesized, and aryl chlorides can be coupled in the presence of aryl triflates. The method is user-friendly, since a commercially available complex, Pd(P(t-Bu)(3))(2), is effective. Pd/P(t-Bu)(3) also functions as an active catalyst for Stille reactions of aryl bromides, furnishing the first general method for room-temperature cross-couplings.