Serum Lipoprotein Profile in Children from a Biracial Community: The Bogalusa Heart Study
Serum Lipoprotein Profile in Children from a Biracial Community: The Bogalusa Heart Study
复制标题
混血儿社区儿童的血清脂蛋白谱：Bogalusa 心脏研究
作者：
S. Srinivasan;R. Frerichs;L. Webber;G. Berenson
作为Bogalusa心脏研究的一部分，研究了一个混血儿社区3182名5-14岁儿童的血清脂蛋白谱，以描述动脉粥样硬化的早期自然历史。白人和黑人儿童的β-脂蛋白平均水平相似。然而，白人儿童的β-前脂蛋白水平明显较高，而黑人儿童的α-脂蛋白水平明显较高。女孩的β水平普遍较高；α-脂蛋白、α-前脂蛋白和α-脂蛋白水平均低于男孩，但各年龄组差异不显著。α-脂蛋白水平随年龄变化不大，β-前脂蛋白水平显著升高，β-脂蛋白水平在11 ~ 14岁之间略有明显下降。α-脂蛋白与α-脂蛋白呈负相关，与前β-脂蛋白呈更大程度的负相关。上述负相关关系在白人儿童中明显大于黑人儿童，这表明两组的脂蛋白谱存在差异。一项全社区研究的脂蛋白值现在可与目前推荐的脂蛋白正常上限进行比较。由于在这个社区中，只有非常小比例的儿童可以被认为是高脂蛋白血症，我们建议使用分布和百分位数来评估儿童是否患有高脂蛋白血症。
SUMMARY Serum lipoprotein profiles in 3182 children, ages 5-14 years, were studied in a biracial community as part of the Bogalusa Heart Study to describe the early natural history of atherosclerosis. White and black children showed similar mean levels of β-lipoproteins. Pre-β-lipoprotein levels, however, were significantly higher in white children, while significantly higher levels of α-lipoprotein were found in black children. Girls had generally higher levels of beta;- and pre-α-lipoprotein and lower levels of α-lipoprotein than boys, although the differences were not significant at each age group. With age there was little change in α-lipoprotein levels, a significant increase in pre-β-lipoprotein levels and a slight but significant decrease between 11 and 14 years in β-lipoprotein levels. The correlation of α-lipoprotein was negative with α-lipoprotein and, to a greater extent, with pre-β-lipoprotein. The above inverse relationships were significantly greater in white children than in black children, suggesting differences in lipoprotein profiles in the two groups. Lipoprotein values from a total community study are now available for comparison with the currently recommended upper normal limits for lipoproteins. Since only a very small percentage of children could be considered as hyperlipoproteinemic by those specific levels in this community, we suggest that distributions and percentiles be used to evaluate children for hyperlipoproteinemia.