Vascular endothelium-derived factors and arterial stiffness in strength- and endurance-trained men
Vascular endothelium-derived factors and arterial stiffness in strength- and endurance-trained men
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DOI：
10.1152/ajpheart.00678.2006
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发表时间：
2007-02-01
影响因子：
4.8
通讯作者：
Miyauchi, Takashi
中科院分区：
文献类型：
--
作者：
Otsuki, Takeshi;Maeda, Seiji;Miyauchi, Takashi
接受力量训练的人的动脉僵硬程度较高，而接受耐力训练的人的动脉僵硬程度较低。然而，这些不同适应的机制尚不清楚。血管内皮衍生因子，如内皮素-1(ET-1)和一氧化氮(NO)，在调节血管张力中起着重要作用。我们假设内源性ET-1和NO参与了不同类型运动训练中动脉僵硬的适应。这项研究的目的是调查接受力量和耐力训练的男性血浆ET-1和NO浓度以及动脉僵硬。年轻的力量训练运动员(SA；n=11)、耐力训练运动员(EA；n=12)和久坐不动的对照组(C；n=12)参加了这项研究。SA组的最大握力和EA组的最大摄氧量明显大于C组。动脉僵硬的指标动脉脉搏波速度在SA组高于C组，而EA组低于C组。此外，我们还使用颈动脉压平眼压计和多普勒超声心动图测量了全身动脉顺应性(SAC)，因为动脉僵硬是顺应性的主要决定因素。SA组SAC低于C组，EA组高于C组，血浆ET-1浓度SA组高于C组和EA组。我们没有发现血浆NO浓度(作为NO的稳定最终产物，即亚硝酸盐/硝酸盐)的显著差异。血浆ET-1浓度与主动脉脉搏波速度和SAC呈线性关系。这些结果表明，内源性ET-1的差异可能部分参与了力量和耐力训练的男性对动脉僵硬的不同适应机制。
Arterial stiffness is higher in strength-trained humans and lower in endurance-trained humans. However, the mechanisms underlying these different adaptations are unclear. Vascular endothelium-derived factors, such as endothelin-1 ( ET-1) and nitric oxide ( NO), play an important role in the regulation of vascular tonus. We hypothesized that endogenous ET-1 and NO participate in the adaptation of arterial stiffness in different types of exercise training. The purpose of this study was to investigate plasma ET-1 and NO concentrations and arterial stiffness in strength- and endurance-trained men. Young strength-trained athletes ( SA; n = 11), endurance-trained athletes ( EA; n = 12), and sedentary control men ( C; n = 12) participated in this study. Maximal handgrip strength in SA and maximal oxygen uptake in EA were markedly greater than in C. Aortic pulse-wave velocity, which is an established index of arterial stiffness, was higher in SA and lower in EA than in C. Additionally, we measured systemic arterial compliance ( SAC) using carotid artery applanation tonometry and Doppler echocardiography, because arterial stiffness is a primary determinant of the compliance. SAC was lower in SA and higher in EA compared with that in C. Plasma ET-1 concentrations were higher in SA compared with C and EA. We did not find significant differences in plasma NO concentrations ( measured as the stable end product of NO, i.e., nitrite/nitrate). The relationships of plasma ET-1 concentrations to aortic pulse-wave velocity and SAC were linear. These results suggest that differences in endogenous ET-1 may partly participate in the mechanism underlying different adaptations of arterial stiffness in strength- and endurance-trained men.