Cross-phase modulation spectral shifting: nonlinear phase contrast in a pump-probe microscope.
Cross-phase modulation spectral shifting: nonlinear phase contrast in a pump-probe microscope.
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DOI：
10.1364/boe.3.000854
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发表时间：
2012-05-01
影响因子：
3.4
通讯作者：
Fischer MC
中科院分区：
文献类型：
--
作者：
Wilson JW;Samineni P;Warren WS;Fischer MC
通过对非线性泵浦-探测显微镜的简单改进，实现了具有非线性相衬的显微镜。该技术通过检测探测脉冲中的泵浦引起的光谱偏移来测量交叉相位调制。在透明介质和吸收介质中均获得了具有非线性相衬的图像。在石蜡包埋的活检切片中，交叉相位调制补充了具有结构背景的化学特异性泵浦-探测图像。
Microscopy with nonlinear phase contrast is achieved by a simple modification to a nonlinear pump-probe microscope. The technique measures cross-phase modulation by detecting a pump-induced spectral shift in the probe pulse. Images with nonlinear phase contrast are acquired both in transparent and absorptive media. In paraffin-embedded biopsy sections, cross-phase modulation complements the chemically-specific pump-probe images with structural context.