Review on prostaglandin and oxytocin activity in preterm labor.
Review on prostaglandin and oxytocin activity in preterm labor.
复制标题
早产中前列腺素和催产素活性的回顾。
作者：
M. Ivanišević;J. Djelmis;D. Buković
足月和早产之间的主要区别在于它们的启动方式。有人提出，足月分娩是由共同终末途径的生理激活引起的，而早产是由激活该途径的一个或多个组成部分的多种病因引起的病理状况。早产时子宫收缩力的增强是由于子宫肌层的激活和刺激所致。前列腺素和催产素浓度增加会刺激子宫肌层。子宫内组织刺激性前列腺素的产生增加通常被认为是导致早产的一系列事件的核心组成部分。前列腺素的作用是介导宫颈成熟并刺激子宫收缩，并通过上调间隙连接、催产素和精氨酸加压素受体以及收缩同步来间接增加子宫底主导的子宫肌层收缩力。作者试图解释催产素在人类分娩中的作用和影响，以及抑制早产宫缩的新疗法。本文作者在世界上首次对人类子宫肌层和蜕膜进行了选择性催产素抑制剂的体外测试。
The principal difference between term and preterm labor is how they are activated. It has been proposed that term labor results from physiological activation of the common terminal pathway, whereas preterm labor is a pathological condition caused by multiple etiologies that activate one or more of the components of this pathway. Increased uterine contractility at preterm labor results from activation and stimulation of the myometrium. Myometrium is stimulated by increased concentrations ofprostaglandins and oxytocin. Increased production of stimulatory prostaglandins by intrauterine tissues is generally considered a central component of the cascade of events leading to preterm parturition. Prostaglandins act to mediate cervical ripening and to stimulate uterine contractions and indirectly to increase fundally dominant myometrial contractility by up regulation of gap junctions, oxytocin and arginine vasopressin receptors and synchronizations of contractions. The authors tried to explain the role and influence of oxytocin in human parturition, as well as the novel therapy in inhibiting the contractions in preterm labor. The selective oxytocin inhibitor was tested in vitro on human myometrium and decidua by the author of this article among the first in the world.