Serum amylase isoenzymes in patients undergoing operation for ruptured and non-ruptured abdominal aortic aneurysm
Serum amylase isoenzymes in patients undergoing operation for ruptured and non-ruptured abdominal aortic aneurysm
复制标题
DOI：
10.1016/s0741-5214(99)70132-1
复制
发表时间：
1999-08-01
影响因子：
4.3
通讯作者：
Bradbury, AW
中科院分区：
文献类型：
--
作者：
Adam, DJ;Milne, AA;Bradbury, AW
目的：以往的研究表明，腹主动脉瘤破裂（AAA）手术患者的高淀粉酶血症与不良预后相关。本研究的目的是首次确定此类患者血清淀粉酶的来源，并检查淀粉酶同工酶表达的预后意义。方法：本研究采用前瞻性临床和实验室研究。该研究包括40例AAA破裂手术患者和10例未破裂AAA手术患者，主要观察指标是术前和主动脉钳释放后6小时用酶比色法测定血清总淀粉酶、胰腺和唾液淀粉酶活性。结果：40例破裂患者中有5例（12.5%）术前总淀粉酶水平升高，10例未破裂患者中有1例（10%）术前总淀粉酶水平升高，31例破裂患者中有7例（23%）术后总淀粉酶水平升高，10例未破裂患者中有5例（50%）术后总淀粉酶水平升高。术前唾液淀粉酶差异（P = 0.05），术后胰淀粉酶差异（P = 0.05）
Objective: Previous work has suggested that hyperamylasemia in patients who undergo operation for ruptured abdominal aortic aneurysm (AAA) is associated with poor outcome. The aims of this study were to determine, for the first time, the source of serum amylase in such patients and to examine the prognostic significance of amylase isoenzyme expression.Methods: This study was designed as a prospective clinical and laboratory study. The study consisted of 40 patients who underwent operation for ruptured AAA and 10 patients who underwent operation for non-ruptured AAA. The main outcome measures were serum total and pancreatic and salivary amylase activities determined with enzymatic colorimetric assay before operation and 6 hours after aortic clamp release.Results: Five of 40 patients (12.5%) with rupture and one of 10 patients (10%) with non-rupture had elevated total amylase levels before operation, and seven of 31 patients (23%) with rupture and five of 10 patients (50%) with non-rupture had elevated total amylase levels after operation. The preoperative salivary amylase (P =.05) and postoperative pancreatic amylase (P