The Time Course of the Probability of Transition Into and Out of REM Sleep
The Time Course of the Probability of Transition Into and Out of REM Sleep
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DOI：
10.1093/sleep/32.5.655
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发表时间：
2009-05-01
期刊：
影响因子：
5.6
通讯作者：
Ocampo-Garces, Adrian
中科院分区：
文献类型：
--
作者：
Bassi, Alejandro;Vivaldi, Ennio A.;Ocampo-Garces, Adrian
研究目的：提出了一个快速眼动（REM）睡眠表达模型，该模型假设潜在的调节机制是不均匀的泊松过程，其显性结果是进入和退出REM睡眠的过渡。设计：基于自发发生的快速眼动睡眠发作（“发作”）和非快速眼动睡眠间隔（“间隔”），使用非线性逻辑回归方法定义3个变量，并在离散的15秒周期内评估：“倾向性”是指在一个时间段内进入快速眼动（rem）睡眠的瞬时速率，“波动性”是指在一个发作期间脱离快速眼动（rem）睡眠的瞬时速率，而“机会”是指在一个时间段内，在给定时间内进入非快速眼动（NREM）睡眠的概率，这是过渡的必要条件。设置：12:12明：暗循环，隔离箱。参与者：16只雄性Sprague-Dawley大鼠。自发睡眠周期。测量和结果：波动性和倾向性的最高水平分别出现在发作和间隔的最开始。新的条件迅速稳定下来，变量分别在1分1.25分和2分50分达到最低点。之后，波动性显著增加，达到接近初始水平的值。倾向适度增加，在长间隔结束时的非快速眼动睡眠中增加更强。短期内平衡可以通过较长的快速眼动睡眠来证明，从而降低下一阶段的倾向。结论：过渡到发作期或间歇期后的稳定和在任何一种情况下保持一段时间后的不稳定可能被描述为发作期和间歇期持续过程的结果。这些过程是转变公开发生的基础。
Study Objectives: A model of rapid eye movement (REM) sleep expression is proposed that assumes underlying regulatory mechanisms operating as inhomogenous Poisson processes, the overt results of which are the transitions into and out of REM sleep.Design: Based on spontaneously occurring REM sleep episodes ("Episode") and intervals without REM sleep ("Interval"), 3 variables are defined and evaluated over discrete 15-second epochs using a nonlinear logistic regression method: "Propensity" is the instantaneous rate of into-REM transition occurrence throughout an Interval, "Volatility" is the instantaneous rate of out-of-REM transition occurrence throughout an Episode, and "Opportunity" is the probability of being in non-REM (NREM) sleep at a given time throughout an Interval, a requisite for transition.Setting: 12:12 light:dark cycle, isolated boxes.Participants: Sixteen male Sprague-Dawley ratsInterventions: None. Spontaneous sleep cycles.Measurements and Results: The highest levels of volatility and propensity occur, respectively, at the very beginning of Episodes and Intervals. The new condition stabilizes rapidly, and variables reach nadirs at minute 1.25 and 2.50, respectively. Afterward, volatility increases markedly, reaching values close to the initial level. Propensity increases moderately, the increment being stronger through NREM sleep bouts occurring at the end of long Intervals. Short-term homeostasis is evidenced by longer REM sleep episodes lowering propensity in the following Interval.Conclusions: The stabilization after transitions into Episodes or Intervals and the destabilization after remaining for some time in either condition may be described as resulting from continuous processes building up during Episodes and Intervals. These processes underlie the overt occurrence of transitions.